Stem Cell Treatments for Autism – James M’s Story

Donna: Hi, I’m Donna McCairn and this is my son…

James: James

Donna: And how old are you James?

James: 14 years old, 15…

Donna: Yeah, 15 in February. So, we came to Stem Cells last September and since then, the changes we’ve seen in James is that his math has really improved. For the first time he got two B’s at the end of last year for school. And then this year he had a target to get 70% mark by June of this year, but he actually got it when, James?

James: This month – for math.

Donna: For your test? And what have you noticed with the stem cells? What things have you found easier?

James: My daily life.

Donna: Such as?

James: Getting ready for school.

Donna: And what about your homework?

James: I’m completing my homework on time.

Donna: And so what we found at home is James is being more self-directed so instead of coming home and struggling to get through all the homework, he’s come home and sort of had that forward awareness where, “I’ve gotta get my homework done because it’s due tomorrow,” and sitting down and starting his homework unassisted, which has been a huge change. And what about with other people? What changes have you felt?

James: I’m talking to more people.

Donna: And are you less shy or more shy?

James: Less shy.

Donna: Ugh Huh. And what happened on this trip to Panama?

James: I made some friends.

Donna: It’s a first. As all the parents know, making friends is the hardest thing, isn’t it?

James: Yeah

Donna: Yeah. Reading people is really tricky. So with our home life, with his siblings, there’s been less arguing, more being friendly, more being able to reason, just not getting so uptight and blocked. He can understand others rather than being self-orientated and only interested in what he needs and getting frustrated. He’s starting to see his sisters’ point of view, But… They’re still not right are they?

James: Um, Hmm. (laughing)

Donna: And it’s those little things. So. James likes to be driven to school, but when I say, “No, you gotta go catch the bus,” he normally would have resisted and waited and waited, but what I’ve notice between the last stem cell visit and this visit is the ability for him to reason, “Okay, mom’s not going to drive me to school today. I just have to get ready and go.” Whereas before, he’d just wait, and just wait until someone just gave in, or at least walked him to the bus stop to get the bus. And what about coming home from school on your own on the bus?

James: I’m more happy.

Donna: And what about walking with the other boys?

James: I talk to them more.

Donna: And do you sometimes walk and get off the bus with the other boys and come the other way?

James: Yeah

Donna: So, it’s like he can get off at a stop where boys from his school get off together, and that’s a very new thing to go, “Oh, I need to be…” We all said, “You need to be in a group. You need pals.” What are you nudging me for? What’s the best thing about coming to Stem Cells?

James: The people and it doesn’t hurt. Oh, bringing your parents.

Donna: No, No, not parents. Being on holidays…

James: With mom.

Donna: Exactly! Being on holidays with mom. So if you want a great holiday, leave the kids. Leave the husband. Just come with your boy.

Stem Cell Therapy for Autism – Brady B’s Story

Interview with the parents of Brady B, during his second round of stem cell therapy for autism at the Stem Cell Institute in Panama using *umbilical cord tissue-derived mesenchymal stem cells.

For more information, visit: https://www.cellmedicine.com/stem-cell-therapy-for-autism/

*umbilical cords donated after normal, healthy births

Interview Transcript

Interviewer: Today is December 22nd 2017. Please give your names.

Michele: Steve and Michelle Bacon and this is Brady.

Interviewer: Brady’s diagnosis?

Michele: Brady was diagnosed when he was two and a half with autism.

Interviewer: So, this would be his second stem cell treatment?

Michelle: Umm, hmm.

Interviewer: The first treatment was performed when?

Michelle: April, 2017.

Interviewer: Can you describe his improvements?

Michelle: The first round of stem cells, after the second infusion, we were putting him to bed that night and he said spontaneously, without any requests or anything, us prompting, nothing…his first 3-word sentence. He said, “I want pizza.”

Steve: When Brady was diagnosed he was, or is diagnosed as non-verbal. So that was a complete surprise that he came up with a spontaneous 3-word phrase.

Michelle: And before that, he had only been doing like “echoing” and a lot of it was not understandable to everyone. I mean, we understood because we know him but other people wouldn’t have been able to understand.

Steve: Since stem cells, he’s become more patient and able to wait for things and not have to quick go and do something. He can stand in a line and wait now.

Michelle: He’s more… His school reported that he is more tolerant of transitions, like when they’re transitioning from a preferred activity to, like, work, like a work sheet – school stuff.

Steve: He’s able to read some sight words now since…

Michelle: About 30. Yeah, he can read words now. He wasn’t able to do that before. He can… It started out just recognizing like, from an array of three pictures, and then he would have like, “apple” or “banana” and he’d have a horse and a pencil and a banana and he cold match the word “banana” to the picture. And he would trade out the words and he could correctly identify which word went with which picture. And now, all we need is the flashcard of the word, no pictures, just like “horse” or “yellow”. And he can identify about 30 words. 30 or 40 words.

Steve: And he can now read some simple sentences with the sight words in it that he knows. And this is all new since stem cell treatments.

Michelle: Yeah, a lot more tolerant. Eye contact is better. He seeks out peers to play now whereas he didn’t before. Greetings are better – like “Hi” and “Bye”. Still working on the eye contact though. That one’s still kind of tough. He can look at you in a mirror, do eye contact in a mirror but the face is a little hard still.

Interviewer: Ok, anything else that you’d like to mention?

Michelle: Anything else guys?

Brother: He’s my brother.

Sister: [Inaudible]

Steve: More interactive with peers and family members.

Michelle: He’s definitely more interactive with everyone.

Interviewer: Ok.

Michelle: And no.. Oh yeah! He used to, it was hard always to get him to come out of his room. He would just want to sit in his room and play on his iPad and now he actually comes out and he sits with us a lot more. And he’s a lot more interactive with the family. We used to have a hard time getting him to stay at the table for dinner and now, he stays at the table no problems. He used to have meltdowns that would last 20 or 30 minutes. Now, he turns around in like, a minute. It’s so much better. His temperament is a lot better. I mean, he’s always been a very good boy but he gets rigid about things, you know? If he doesn’t have it just that way, it’s a 20 – 30 minute meltdown – before. Now, it’s much better.

Interviewer: Ok. That’s it. Thank you very much.

Everyone (including Brady): Cheese!

Stem Cell Therapy for Autism – Clara Goodman: ‘Never Give Up on Your Child’

Image of stem cell therapy patient Ari Goodman

 

By Jill Kirsch | December 28, 2017
Original Publication on Jewish Link of New Jersey

Following Ari Goodman’s first stem cell therapy last year, to treat what doctors called severe low-functioning autism, The Jewish Link reported on his progress and his family’s hope that they would be able to help him continue his journey towards recovery.

Ari was first diagnosed seven years ago, after he began losing skills at the age of 18 months. His mother, Clara, and father, Daniel, a 1990 graduate of Frisch who grew up in Parsippany, explored all therapies available to Ari, but nothing was able to reach him.

The family persevered, finally learning of the Stem Cell Institute, a facility in Panama that was known for successfully administering stem cell therapy to patients with autism. Clara and Daniel were determined to help Ari receive that treatment but, with the procedure and other costs totalling nearly $20,000, they feared it was beyond their reach.

Clara, ever her son’s champion, reached out to The Jewish Link, seeking assistance in sharing her family’s story, and the response went well beyond what they imagined. The Goodmans, residents of East Windsor, were able to take Ari for his first treatment in May of 2016, and the results, noted Clara, were “miraculous.” Within weeks the family saw Ari begin “coming back to us. We started to see changes,” she said.

Feeling eternally grateful to the greater Jewish community for its help, and hopeful for the first time in years, Clara again reached out, in December of 2016, through a follow-up article in The Jewish Link. This time the Goodmans were not surprised by the outpouring of support, but just as grateful. “It is amazing how many people are right there with us. Everyone who has cared about our story has helped in some way,” Clara remarked.

Ari, now 9 years old, received his second stem cell therapy earlier this year, and Clara was thrilled to discuss his progress with The Jewish Link. “Since February, his awareness of everything is 100 percent there,” she said. “He responds. His receptive language is amazing. He’s able to answer questions. He just knows everything and has opinions.”

Clara reports that Ari is now able to spontaneously ask for things and express wants and needs, though still only using one word at a time. “He has a sense of humor now. He laughs,” she said.

He is able to read sentences, and can spell words and put them together to form sentences. In fact, at school Ari is no longer in the class for children with autism; his progress has allowed him to move to a class for students with “multiple disabilities,” where the students are more social and conversational. His teachers have told Clara that Ari adds much to the classroom, and both students and teachers enjoy having him there.

“My hope is that he’ll develop more language,” said Clara. “I hope to mainstream him and maybe have him attend a Jewish school one day. We would love for him to learn Torah every day.”

For the first time, Clara is anxiously awaiting Ari’s annual IEP (Individualized Educational Plan) meeting next month, as she has already been told by his teachers that he has met all of his goals and they want to expand on that for next year. “I used to dread those meetings,” she stated. “Now I can’t wait. I’m looking forward to every day and seeing what new things he can do.”

Ari is “loving and affectionate, full of hugs and kisses,” Clara reported. “Doctors said he’d never do that.”

She continued, “We were told he would never be able to do any of these things. He is showing more every day that he’s whole. It’s in there and once the stem cells heal him it will all come back. He is proving everybody wrong and showing that Hashem is in charge, not any doctor.”

The Goodmans are hoping that a third treatment will “show more revealed miracles,” added Clara. He’s not conversational yet; I want the social aspect to come. I know he’s not out of the woods yet. He has a long way to go,” but “every time we go we see more and more improvement.”

While trials using adult stem cells are now ongoing at Duke University in North Carolina, America still does not have any treatments available that might benefit Ari. “We are that much closer to the FDA approving treatment,” Clara said. “But even then it still might not be covered.”

In the meantime, the Goodmans believe they must continue these treatments. “The stem cell therapy is allowing him to respond to all the therapies that weren’t working before. His body is healing and is open to it now,” added Clara.

“I feel like I have him back again and it’s the most wonderful feeling in the world,” she continued. “We felt like we lost him when he was diagnosed. Ari is proof that miracles do happen.”

“Ari has been through so much and he is still such a happy kid. He inspires others. I really believe that his mission in life is to heal the world; he’s helping us all be better people,” Clara stated. “His middle name is Netanel, which means ‘gift from God.’ He really is.”

Clara hopes that her family’s journey will provide strength to others who have children with autism. “There is an answer. Don’t ever give up on your child,” she said.

To help the Goodman family provide another stem cell treatment for Ari, please visit www.gofundme.com/aristemcelljourney or, to make a tax-deductible donation, send a check payable to “Congregation Toras Emes,” with “for Ari Goodman” noted in the memo line, and send ℅ Clara Goodman to 523 Nettleton Drive, East Windsor, NJ 08520.

By Jill Kirsch

Video: Stem Cell Therapy in Panama with Dr. Riordan and Mel Gibson

Host Michael Beattie discusses stem cell therapy using *human umbilical cord tissue-derived mesenchymal stem cells (hUCT-MSCs)  at the Stem Cell Institute in Panama with renowned applied stem cell scientist and founder, Neil Riordan, Pa, PhD and acclaimed actor, director and producer Mel Gibson.

Dr. Riordan discusses the miraculous progress of a spinal cord injury patient and pilot whose doctors said that he would never walk again.  He talks about where the stem cells come from, how they work and why they can treat so many seemingly different conditions.  Dr. Riordan explains how umbilical cords, and subsequently, hUCT-MSCs used at the Stem Cell Institute are carefully selected using molecular screening.  He also discusses why mesenchymal stem cells from umbilical cords function better than MSCs from adults, especially as they age or if they are suffering from a disease like multiple sclerosis.  For example. MSCs from a newborn multiply exponentially compared to MSCs from an older adult.

Mel Gibson discusses his father’s miraculous recovery, literally from his deathbed after receiving hUCT-MSCs at the age of 92.  He’s currently 99 and still going strong having been treated in Panama several times since then.  Mel also discusses his personal experiences in Panama.

Watch all this and more.

*umbilical cord tissue harvested after normal, healthy births

Stem Cell Therapy for Autism – Dimitri W’s Story

For more information about stem cell therapy for autism please CLICK HERE.

Dimitri’s parents discuss his progress after his first round of stem cell treatments for autism in Panama.

Interviewer (I): Today is August 4th, 2017. Please give your name.

Dimitri (D): Dimitri

(I): Your last name?

(D): Weaver

(I): Your age?

(D): Six

(I): Mom, his diagnosis?

Mrs. Weaver (MOM): He was diagnosed with autism at the age of three.

(I): Ok, so this is his second stem cell treatment?

(MOM): Second stem cell treatment, yes, about a year apart.

(I): Can you describe his improvements?

(MOM): I’ve definitely seen a lot of growth since last year, mostly in language [and] comprehension. He started school last year. He’s reading. We’ve notice a lot of changes with being able to sit still and focus at school. We’re still struggling in that area but last year we weren’t sure if he was going to be able to go to kindergarten and he’s doing well. His first year, he’s now participating in sports. He just started karate, and doing really well with that. Mr. Weaver

Mr. Weaver (DAD): I think that, yeah, he’s had a lot of remarkable changes in the past year. He’s done really well with kindergarten as you’ve said.

(MOM): Overall, the teachers that saw him last year for evaluation for his IEP – and then we had an IEP meeting this May, not even a year apart. They said he looks like a different child. So they weren’t expecting the growth that he’s made this year in school.

(I): Anything else you would like to mention? (MOM): We haven’s seen any regressions or any negative, no side effects. All we’ve seen is growth. That’s why we’re here again this year. It’s been all positive for us.

(DAD): It’s been a great experience.

Stem Cell Therapy for Autism: John Guerriero Interview with Neil Riordan, PhD, PA

John Guerriero discusses the progress of his son Anthony with Neil Riordan, PhD, PA after undergoing stem cell therapy at the Stem Cell Institute in Panama City, Panama. Anthony was treated with human umbilical cord-derived mesenchymal stem cells. The umbilical cords were donated by mothers following normal, healthy births.

Stem Cell Thearpy for Autism – Interview with Stephen Lallo and Neil Riordan, PhD, PA

Stephen Lallo discusses his son Jack’s improvements after undergoing stem cell therapy at the Stem Cell Institute in Panama City, Panama. The treatments us human umbilical cord tissue-derived mesenchymal stem cells. The umbilical cords are donated by mothers following normal, healthy births.

How Stem Cell Therapy Saved My Son

autism_hope_alliance_web_liogo_copy

By Susie Reveles September 11, 2016
View Original Interview

Interview with Marty Kelley – Mother, Wife and Stem Cell Advocate

kelley-family-in-panama
She fought for her son and won. She never gave up and followed her instincts. Her message is one of Hope, Determination and Unconditional Love. The Autism Hope Alliance had the pleasure of learning more about her journey and hearing her story.

Autism Hope Alliance:

Can you tell us what is Stem Cell Therapy and why you are so passionate about it?

Marty Kelley:

We received stem cell therapy at the Stem Cell Institute in Panama, which is where all of Ken’s treatments have taken place, they use stem cells harvested from donated human umbilical cord tissue after normal, healthy births called mesenchymal stem cells (MSCs). Umbilical cord tissue is a rich source of the most potent MSCs, which modulate the immune system and possess anti-inflammatory properties. Each donating mother is tested for infectious diseases and has her medical history screened. Proper consent is received from each family prior to donation. Before they are approved for use in treatment all umbilical cord-derived stem cells are screened for infectious diseases to International Blood Bank Standards. Only a small percentage of donated umbilical cords pass the rigorous screening process.

The actual treatments are relatively simple. There are just several quick intravenous injections of the purified MSCs over the course of several days. Each injection only takes a few minutes. Autism (and its degree of severity) has been significantly correlated with elevated levels of macrophage-derived cytokines (MDC) and thymus and activation-regulated chemokine (TARC), both of which are implicated in neuro-inflammation. Intravenous administration of umbilical cord MSCs can reduce inflammation in the brain and throughout the body, thus lowering the levels of MDC and TARC and improving a child’s symptoms. This is the rationale behind the treatment, which is currently in the process of being tested in controlled clinical trials.

Autism Hope Alliance:

What changes if any did you see in your son after doing it?

Marty Kelley:

After doing our first stem cell treatment, Kenneth started talking about the past for the first time! Within a few months, he was able to have simple conversation and at nine months after the cells, Kenneth potty trained and started reading. It was a few months before his ninth birthday.

ken-kelley-with-dog

Autism Hope Alliance:

How long before you noticed any changes?

Marty Kelley:

Before stem cells, my husband and I categorized Ken as moderately to severely autistic. So, it was while we at the Stem Cell Institute getting our first stem cell treatment, where Ken started speaking clearer and adding more words to his limited sentences, we knew the cells were working. Changes continued to occur daily, such as Ken having a concept of time, describing his trip to Panama as “four hours in the car and 8 hours on the plane” in a news interview 2 weeks after getting cells!

Autism Hope Alliance:

What therapies did you do before trying Stem Cell Therapy?

Marty Kelley:

Like most parents on this journey, we tried biomedical intervention intensively before stem cells, starting when Ken was 6 years old. We bought a mild hyperbaric oxygen chamber for our home and treated him for two years with 900 hours of dives. Also, we used around 30 different vitamin supplements as well as the Specific Carbohydrate Diet, along with fermented foods. We used the top autism biomedical doctors at the time (2006-2009), including having Ken’s gastrointestinal issues diagnosed with Dr. Arthur Krigsman at Thoughtful House and QEEG scans to give us markers for improvements.

Autism Hope Alliance:

How did you even hear about stem cell therapy and how did you decide on the clinic to go to?

Marty Kelley:

A news story in Orlando, Florida, introduced us to stem cell therapy and Daniel Faiella, a father who had treated his son at the Stem Cell Institute. I called Daniel every day for two years while I researched adult stem cells. It was still hard to decide on a clinic to use. I chose the Stem Cell Institute because of their reputation and what I researched. And a great quote that sums it all up is, “You cannot always wait for the perfect time, sometimes you must dare to jump.” As long as I was sure that umbilical cord cells would not cause any harm, it was just a matter of taking the “jump.”

Autism Hope Alliance:

Where was your child before Stem Cell Therapy?

Marty Kelley:

Before stem cells, Kenneth was out of control. He could not have a conversation with us. He could not tell us spontaneous things, like what happened at school, if he was sick or hurt, or things he needed. Ken often screamed and yelled and was violent and threw things and would run awayfrom us, ripping his clothes off, running naked. At the time, our physician did not know anything about stem cells, but recommended that we place Ken in an institution because of his out of control behavior. This devastated us.

In a documentary film featuring Ken’s story, we tried to capture the essence of Ken’s life before stem cells and then show the changes from the cells. This film is called Ken’s Journey To Recovery and can be viewed on YouTube at https://www.youtube.com/watch?v=-FaGf0h20Vw

Autism Hope Alliance:

Paint us a picture of where he is today?

ken-kelley-today

Marty Kelley:

Today, Ken is calm, peaceful, and polite–the sweetest joy in our lives. He is what life should be, happy and caring and intuitive. Ken has a passion for learning, I think because of all of the gaps with the autism. Even his teachers recognize his passion and he recently received an award in History in a mainstream classroom out of 70 neuro-typical peers.

Autism Hope Alliance:

How many stem cell treatments did he get and do you do any therapies with him currently?

Marty Kelley:

From 2009 to 2012, Ken has had six stem cell treatments. We have not had him on any diet or supplements since 2012. Our lives are very normal with limited therapies, except for speech therapy and school. We have not done any biomedical since 2009.

ken-kelley-at-fair

Autism Hope Alliance:

What advice would you give to someone who is thinking of doing Stem Cell Therapy?

Marty Kelley:

If parents were considering stem cells for their child, I would recommend lots of research. Make sure you know that the treatment is safe and find a clinic with a good reputation. And don’t wait. Stem cells are amazing, but, like any medical treatment, it doesn’t work for everyone. For your child, however, it may be worth a try.

“Dream big dreams, small dreams have no magic”

For more info:

www.KensJourneyToRecovery.Blogspot.com

https://www.facebook.com/marty.kelley.9

https://www.youtube.com/watch?v=-FaGf0h20Vw

https://www.youtube.com/watch?v=B6T9MZYM_wY

https://www.youtube.com/watch?v=jyU4m2ZF-pA

https://www.youtube.com/watch?v=csJGUbonU4k

*This interview is not intended to diagnose, treat, cure or prevent any disease. It is for informational purposes only. Each parent knows their child the best and we recommend individuals to consult their doctor before considering any therapy or treatments.

Neil Riordan, PhD discusses stem cell therapy on Larry North’s “Better you Show” – CBS KRLD 1080am

Picture of Larry North

Larry North

KRLD 1080

Larry North has been helping people become healthy for over 25 years. He’s done this with three best-selling books, seminars, and gyms. These people were no different than you. The only difference is that they chose to make a change in their life. Now it’s your turn. Don’t put it off any longer. Let Larry help you become an even better you. Here’s Larry North.

Larry: Hey everyone. We had a cold front. It went from 105 degrees down to 97. It was really like a cool breeze for everyone in North Texas. This is the Better You show. I’m just thrilled! I’m always seeking to help you in my quest to deliver the best experts, the best guests, the best technology, the best medical advice that you could possibly get; be it exercise or nutrition, and of course your health. My guest is Dr. Neil Riordan, chairman of MedStem out of Panama. There’s so much to talk about. He’s published dozens and dozens of scientific articles, [and] internally peer reviewed journals. He’s just a cutting edge expert when it comes to stem cells. In fact, he and his colleagues have published articles together on MS, spinal cord injuries, heart failure, arthritis, autism. He’s also CEO of Riordan-McKenna Institute right here in Southlake. So he’s local, but he’s actually more international that he is local. Just happens to be close by, consults with numerous universities, and I consider him a friend. You flew in from Wichita, which is where you’re from, right?

Image of Neil Riordan, PA, PhD

Neil Riordan, PA, PhD

NR: Yeah, that’s my hometown. We were doing a fund raiser for a young man who has Duchenne’s muscular dystrophy, and originally we started treating him in Panama using stem cells from umbilical cords, and he responded very well, and he responds each time he gets treated, but we have to keep treating him. It’s a very long-term treatment. He has to get new cells every 4-6 months. He is the first person in the US to get umbilical cord stem cells for any indication, and we’re under the FDA. They’ve given us an investigational new drug, compassionate use, because he was treated seven times out of the country, but they gave us the green light for him to get treated in the country. He’s been treated now three years, every four months now, and when he gets those stem cells his breathing goes up, everything improves. In fact, now, eight years later since his first treatment, he’s in better health now than he was at 22, and he’s about 30 and a half.

Larry: I’ve been around you long enough and I’ve heard these types of stories, I really hope we can inspire a lot of our listeners. I’d like to start from the beginning. Your father was really kind of a holistic pioneer when it came to better health, was he not?

NR: Absolutely. My father and later myself, we did a lot of work on cancer therapy, and what we worked most on was intravenous vitamin C for cancer treatment, decades ago, back when that was really quackery. Now we have universities like Thomas Jefferson starting their third clinical trial using intravenous vitamin C for cancer patients, university of Iowa, even Johns Hopkins has started a study. Some of these ideas take time to catch on, but they’re really catching on now.

Larry: What was it like growing up with a father so cutting edge, so way ahead of his time?

NR: I think in retrospect now I realize how brave he was in doing the things he was doing. As my brother says, you can recognize a pioneer by the arrows in his back. He certainly had a few, but I think his legacy is that those arrows were unwarranted, and now you have major universities carrying on the research. The quality of life of cancer patients when they get intravenous vitamin C has improved. It’s been proven. More and more literature comes out, and he’s being vindicated.

Larry: What I’ve found, and this is why I’m so excited to have you, what I’ve found is that I know just enough about stem cells to really be dangerous when I try to educate people, and I don’t. Most people really have no clue. They’ve heard of stem cells. They think they know a little bit about it, but they’re really not sure. They’ll just be inquisitive. Where did all the stem cell research start?

NR: It actually started with one of our other research projects alongside the vitamin C research at the Riordan Clinic in Wichita, where we were looking at host non-toxic therapies for cancer. One of them…, there are cells in your body called dendritic cells. They are commanders of the immune system. They tell the immune system what to do, and in cancer patients they’re being blocked. One way to overcome that blockade to the immune system is by enhancing these dendritic cells and harvesting white blood cells to convert to dendritic cells. That was late 80s, and I left in the 90s to start my own clinic to actually make dendritic cells, to make cancer-therapeutic vaccines for cancer patients. I was in the Riordan Clinic for fourteen years, working on intravenous vitamin C and dendritic cell vaccines.

Larry: Interesting. What are the most common types of stem cells people have available to them today? I want to talk about that, and also, why umbilical? From what I’ve read, if you want stem cells that’s where you want to go, but I understand there are other options. You were able to treat this young man locally, but most people have to go out of the country. What were the early stages of stem cell options for people and where has it evolved to?

NR: First I want to exclude embryonic and fetal stem cells, which are subject to a lot of debate–religious and ethical–and we want to exclude that because that’s not even part of our conversation. It’s from an ethical and scientific standpoint that we’ve never utilized or even studied embryonic or fetal stem cells. We only use what’s classified as adult stem cells, and what’s included in that, is after a full-term healthy birth, we call those post-natal or adult stem cells. Once a healthy, normal life has begun on until your demise, those are all considered adult stem cells, and we can separate those into two major categories: one is blood-forming stem cells that are formed in your bone marrow, and those are called hematopoetic stem cells or blood-forming cells because that’s what they do. There’s a lot of confusion these days about those cells being used to treat cancer or MS, but those cells don’t really treat anything. When you hear about a cancer patient being treated with stem cells, they’re actually being treated with chemotherapy and/or radiation, in the hope that they get a high enough dose to kill the cancer, but it also kills your bone marrow’s ability to produce blood cells, so you die of an infection or you die of bleeding or something like that. The stem cells in that world are a rescue, not a treatment. Your stem cells are gone. They’ve all been obliterated, so you need new stem cells and start making all these blood products again. The world we’re in are repair stem cells -the repair stem cells are found throughout your body called MSCs. We use the term MSC for mesenchymal stem cells. We have them throughout our body and as we age, they become fewer in number, and as we age they lose their ability to fix things. They become less robust. So you have them in your fat, your bone marrow, every organ in your body. The healthiest, most robust stem cells from a non-dangerous, non-controversial source are from the umbilical cord. If we look at the potency of umbilical cord MSCs compared to mine, I’m 57 years old, my cells are going to divide once every 50-60 hours, whereas the umbilical cord cells divide every 24 hours, which doesn’t sound like a lot, until you look at the numbers. One cell after 30 days you’re going to have a billion cells from one if they divide every 24 hours. If you look at my cells in a lab, I’ll have a pitiful 2-300 cells after that period of time. It’s not just the cells, but it’s also what the cells secrete, molecules that stimulate regeneration. Our cells because we’re over the age of 50, they do not produce as many of those factors that stimulate regeneration, they’re also less robust their capacity to modulate the immune system and decrease inflammation. We all know that inflammation is the real key to aging.

Larry: You’ve touched on a lot of things. You are so brilliant and so smart. You’re a scientist. One of the great things about having you, is that this is the future of medicine, and being able to explain to people how they work. I want more stories from people who are actually, truly changing their lives as the result of stem cells, but I also want to talk to you about the confusions. I’ve had some friends who have gone to Houston and had some body fat taken out of their body, processed, and what are the benefits of that vs. umbilical? We’ll come back and talk about that. [Commercial break] We’re talking about the umbilical stem cells. Let’s say someone lives in Dallas. How would they know if they’re a candidate for stem cells?

NR: Typically we would want them to go to our website, and we’d want them to read all about what we do what we don’t do there. [www.cellmedicine.com]

Larry: So let’s say they go to the site, and one of my sponsors here is BioMedical and they’re about hormone optimization, and I love that your clinic actually does BioT. So if you’re thirty, and you test your testosterone levels and it’s high, let’s say above 800, they’d tell you you’re not a candidate for it. What tells you about who needs stem cells?

NR: We have a number of protocols. One of the things we do most of is we treat autoimmune diseases, and one of the indications we have is multiple sclerosis, rheumatoid arthritis and others. The cells are very good when you infuse them in the vein. They change the auto-immune environment in the body. If someone wants to explore it as a treatment option, they’d go to the site and read about what we do and fill out an application. We have six MDs that work at the Stem Cell Institute in Panama. They review every case and will call them and typically ask them for medical records.

Larry: I’ve been there, to Panama, visited and got to work with your medical professionals, and I found it an amazing experience because for me, it was orthopedic because of the fact that I was a body-builder back in the 70s and 80s and we did things back then we probably shouldn’t have done. We sort of didn’t know any better. After being in several auto accidents, my neck, my back, my knee, and I have to tell you I had stem cells directly into the knee, and prior to meeting you I thought I was going to have to have surgery. In the month or so since we last saw each other, I don’t know what’s going on in my body but I’m feeling amazing. I want more of that! For me it was orthopedic. For others listening, you talked about inflammation, and stem cells are definitely able to help with that.

NR: Absolutely. They’re producers of the anti-inflammatory molecules in your body, the producers of your natural ibuprophen or naproxine. A lot of people, if they have a lot of arthritis, that’s another one of our protocols. Osteoarthritis, they don’t need to take those things anymore. We can inject right into the joint as well as do intravenous [injections]. The cells have this capacity to home to inflamed areas and respond to the situation to make the appropriate antibodies.

Larry: Let’s open up the phone lines. Let’s go to Said in Arlington:

Said: I am 60 years old and have been diagnosed with diabetes for six years. My A1C average is about 7-7.2. My question is, is there any research on diabetes and diabetic people? Will what you do help me?

NR: We don’t treat Type 2 diabetes in Panama, but there was a very good study done by the University of Miami, and they used bone marrow stem cells from the patient themselves, isolated the stem cells and pushed the stem cells into the pancreas, and if I remember correctly got a reduction in hemogloben A1C of 2.5 points was the mean for 20-some patients. I can post that study to my blog for you.

Said: Did that study proceed further?

NR: That was a one-time study and they followed the patients for a year. The procedure itself took one day, the bone marrow harvest, concentrating, and then the injection.

Said: What I have read, all these pharmaceutical companies are making money, tons of money, so naturally they don’t want anyone to promote to cure this disease. I’m sure there is a cure but no one wants to do the research.

Larry: Also, with Type 2, you do want to exercise, eat right, have your hormones in balance, take good care of yourself. That’s one of the best ways you can deal with your overall health and wellness, which you do control. Good luck to you. Neil, so, help me out here. Stem cells is a hot topic right now but you’ve been doing this for decades. You’ve devoted your life to it. I’ve seen and I’ve read on social media that locally, people are offering stem cells you can get locally. But really, without that special dispensation you have for one patient, what are people doing that are saying they can get it from a local clinic here.

NR: In our case at RMI in Southlake, we do stem cell therapy but we’re limited by FDA to using the patient’s own bone marrow. We also use amnion from afterbirth that has growth factors to make your bone marrow perform younger. We’ve got Dr. Wade McKenna, our board certified orthopedic surgeon. He does treatments using the patient’s own bone marrow in a relatively painless extraction procedure. He uses that in combination with amnion and with surgery. In his words, he likes to take big surgeries and make them small surgeries, and small surgeries and make them injections.

Larry: It’s a relatively new clinic but he’s busy, right?

NR: Yep, he’s done thousands of surgeries using bone marrow in Decatur and now he’s here, only for orthopedics, but we have another doctor there for overall wellness and optimization and hormone replacement therapies.

Larry: What led you to umbilical stem cells over other forms of stem cell treatment?

NR: It was mainly the science. One of the misconceptions is that the cells actually become new tissue. We have people come to us asking for new bladders and new body parts. These cells do not do that. These cells do home to places of inflammation in your body. That’s the sweet spot for these MSCs and they secrete substances that turn off these inflammations, and another sweet spot is autoimmune disease. If you look at what they secrete and their activity on the immune system and compare that to fat stem cells, you can get MSCs from your own fat, if you compare that, you have way more modulation potency from the umbilical cord than you do from your fat.

Larry: That’s quite significant.

NR: Basically you have to get this rock over a hill from an immune standpoint, and you can get halfway up the hill and it doesn’t do any good. If you want to get the rock over the hill, the best way to do it is with the best cells that produce the right molecules that stimulate your immune system to normalize.

Larry: The science agrees with you, there’s no question, but in the early stages, where did you go to get the cells in the first place?

NR: In Southlake, we have specialized equipment that allows us to take out the bone marrow, and we also have the amnion product that “hops up” the bone marrow. In Panama, we have a 16,000 square foot laboratory where we isolate the stem cells from umbilical cells, grow them out, freeze them down, and then we thaw them as required for use. All the hard work in Panama is in the laboratory because the actual therapy is nothing more, as you know.

Larry: Now, are there a lot of labs in the world that produce those types of cells?

NR: There’s about a handful. We’re creating a wedge with this Duchenne’s, and we’re creating a wedge for larger studies with more individuals.

Larry: Our callers touched upon it a little bit with pharma, I imagine there’s a lot of red tape and lobbying and I imagine pharma’s a lot of the pushback on why you’re not able to have your labs all over the United States.

NR: If you take rheumatoid arthritis as an example, and there was a study that came out where they treated over 172 people with umbilical MSCs, and all of them improved, after one infusion.

Larry: This is huge for those patients, because it’s very painful and there’s no cure before stem cells.

NR: If you look at the drugs that you hear about all the time watching television, you see these anti-rheumatic drugs over and over again, and they represent a 14 billion dollar industry in the US. So if you have a competitor that’s not yet FDA approved, there’s not going to be a great deal of pharma support for that.

Larry: Am I wrong in believe that the future is here, stem cells are going to be much bigger in peoples’ lives than they ever imagined?

NR: Yeah, I think it’s definitely right up there with vaccinations and antibiotics as far as the next leap forward in medicine, and as congressman Joe Barton pointed out in a meeting we had a couple of months ago, the truth always comes out. Sometimes it takes longer, and in this case the effectiveness of these cells, the safety of these cells, the naturalness of these cells, all those truths will become self evident at some point. How long it takes, I don’t know. There are other countries investing and building a regulatory process that will speed things up. For example, Japan has put in rules and regulations that will speed things up. Germany, South Korea, and Taiwan are right behind Japan. They’re going to allow for innovation like we’ve never seen before. If we don’t do something in this country, we’re going to be left in the dust. So, Japan’s rule basically states that once you prove the safety of your product, it can go to market for seven years, and in that seven years you can demonstrate what it’s effective for. I think we need something like that in this country if we’re going to stay competitive. There’s a bill being revised right now called the Renew Act. I don’t know that that’s going to make it, but we need something like it or for one of the states to create a statute much like medical marijuana, where the state of Colorado has said in spite of federal regulations we’re going to allow this and the attorney general’s going to back us up. I think Texas has a pretty good chance of that. I just got back from Kansas, and they’ve got a pretty good chance too.

Larry: Partly because of you! You’re at the forefront pushing and lobbying and really trying to create awareness.

NR: If you look at the economic benefit, I hate to use marijuana as a comparative, but if you look at the economics in Colorado, the state coffers are swollen with cash, and I think that would happen if a state were to say to the federal government, this is what we’re going to do. There’s enough evidence of safety, certainly with the patient’s own stem cells, with the post-natal stem cells, there’s enough safety data that one state will stand up, or the federal government’s going to have to make a break.

Larry: Any parting words?

NR: I think the best resource is www.cellmedicine.com and RMIclinic.com. It tells you everything we do and don’t do.

Stem cell pioneer sets sights on Japan – Japan Times features Neil Riordan, PhD of Medistem Panama

Japan Times Article Medistem

“We enjoy the advantage of having a large amount of clinical data on 2,000 patients. So we analyzed who received which cells and which cells worked best in different conditions. This allowed us to create our selection process through molecular profiling,” explained Medistem (Panama) Founder and CEO Dr. Neil Riordan.

Operating what is arguably the country’s most advanced laboratory, an 8,000-sq-ft facility in the City of Knowledge science and technology cluster, Medistem has raised its profile in recent years as it develops stem cell-based products for clinical trials for treatment of autism, asthma, multiple sclerosis, osteoarthritis, rheumatoid arthritis and spinal cord injuries.

Utilizing its patented technologies, Medistem harvests human adult stem cells from umbilical cords, tissues and blood as well as from bone marrow and adipose tissue. “We have intellectual property on a methodology for basically defining which are good cells, which are mediocre and which are the useless ones. The U.S. Food and Drug Administration has approved our cells for compassionate use in the United States. This is a big step,” Riordan said.

Compassionate use, also known as expanded access, refers to the use of investigational new drugs outside of a clinical trial by patients with serious, life-threatening conditions. After finishing its first prospective clinical trial, and with six others in the pipeline, the company is considering the favorable regulatory conditions for cell therapy in Japan, now a promising market for its products.

“Japan has a law on the books that allows a company of our size to commercialize such products. That makes it our number one priority. We are gearing up to present our data to regulators, as well holding talks with potential partners over there,” Riordan added.