As we age our bodies undergo, at varying rates, a series of changes that move us away from homeostasis — or perfect biological balance — and toward a decreased ability to adapt to both internal and external stress, which leaves us more vulnerable to disease. In some people the effects of aging are pronounced, characterizing them as frail — with decreased strength, endurance, physiologic function, and activity, all associated with poor health outcomes. Perhaps you have known people who were dependent on others for their everyday needs — shopping, cooking, and caring for themselves. These are the hallmarks of frailty of aging.
Various studies have concluded that human umbilical cord tissue-derived mesenchymal stem cells (hUCT-MSCs), which are similar to the Golden Cells™ we use at Stem Cell Institute, can regulate the immune system, and reduce systemic inflammation. These effects may occur in patients with overactive or underactive immune systems, and/or systemic inflammation who undergo our Frailty of Aging treatments.
A recent phase II clinical trial from the University of Miami on mesenchymal stem cell therapy for aging frailty using allogeneic mesenchymal stem cells (hMSCs) concluded that: “…Treated groups had remarkable improvements in physical performance measures and inflammatory biomarkers, both of which characterize the frailty syndrome…”
A number of animal studies (in mice) have demonstrated the rejuvenation effects of growth differentiation factor 11 (GDF11), which is produced by hUCT-MSCs. These effects include: reduction of cardiac hypertrophy (abnormal enlargement, or thickening, of the heart muscle), promotion of new blood vessel growth, increased blood vessel volume, neurogenesis (the growth and development of nervous tissue), and muscle rejuvenation (including increased endurance and grip strength) – to name several.
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It was like he got a new lease on life.
One of our staff physicians will assign a stem cell treatment protocol after you have submitted all requested medical information and received approval. Your recommended protocol may differ from the example given below:
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No stem cell product from any source, including the patient’s own, is approved by the US FDA to treat frailty of aging.
However, human umbilical cord tissue-derived mesenchymal stem cells that were isolated and grown in our laboratory in Panama to create master cell banks have been used in the United States under US FDA regulation.
These cells served as the starting material for cellular products used in MSC clinical trials for two Duchenne’s muscular dystrophy patients under US FDA’s designation of Investigational New Drug (IND) for single-patient compassionate use. (IND 16026 DMD Single Patient).
The body’s immune system is unable to recognize umbilical cord-derived mesenchymal stem cells as foreign, and therefore they are not rejected. Human umbilical cord tissue stem cells have been administered tens of thousands of times at the Stem Cell Institute, and there has never been a single instance of rejection (graft vs. host disease). As a matter of fact, allogeneic (not the patient’s own) mesenchymal stem cells are approved to treat graft vs. host disease in Canada and New Zealand.
Umbilical cord-derived mesenchymal stem cells also proliferate/differentiate more efficiently than “older” cells, such as those found in the fat, and therefore, they are considered to be more “potent”.
The adult stem cells used to treat frailty of aging at the Stem Cell Institute come from human umbilical cord tissue (allogeneic mesenchymal). These stem cells are expanded at Medistem Panama’s state-of-the-art laboratory.
The mesenchymal stem cells we use are recovered from donated umbilical cords following normal, healthy births. Each mother has her medical history screened and is tested for infectious diseases. Proper consent is received from each family prior to donation.
All umbilical cord-derived stem cells are screened for infectious diseases to International Blood Bank Standards before they are cleared for use in patients.
Only a small percentage of donated umbilical cords pass our rigorous screening process.
Proper follow-up is an essential part of stem cell therapy. Our primary goal is to ensure that you are progressing safely. Regular follow-up also enables us to evaluate efficacy and improve our treatment protocols based on observed outcomes.
Therefore, our medical staff will be contacting you after 1 month, 3 months, 6 months, 9 months, and 1 year to monitor your child’s progress.
You can apply today to find out if you are eligible for treatment. You may also contact us by telephone 1 (800) 980-7836 (toll-free in US) and 1 (954) 358-3382 (International).