Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy

Nina Mikirova, Neil Riordan, Joseph Casciari Med Sci Monit 2016; 22:14-25 DOI: 10.12659/MSM.895368 BACKGROUND: Cytokines play an important role in tumor angiogenesis and inflammation. There is evidence in the literature that high doses of ascorbate can reduce inflammatory cytokine levels in cancer patients. The objective of this study was to investigate the effect of treatment…

The dual effect of MSCs on tumour growth and tumour angiogenesis

Michelle Kéramidas, Florence de Fraipont, Anastassia Karageorgis, Anaïck Moisan, Virginie Persoons, Marie-Jeanne Richard, Jean-Luc Coll and Claire Rome Abstract (provisional) Introduction Understanding the multiple biological functions played by human mesenchymal stem cells (hMSCs) as well as their development as therapeutics in regenerative medicine or in cancer treatment are major fields of research. Indeed, it has…

Killing of the iPS Field?

Zhao et al. Nature. Embryonic stem cells are associated with numerous ethical dilemmas. The creation of equivalents of ES cells through retrodifferentiation led to a new area of research that does not require destruction of life. Specifically, it was discovered that any adult cell can be transfected with several genes, which results in the cell…

World’s First Chemical Guided Missile Could Be the Answer to Wiping out Cancer

A research team at Deakin University has made a discovery that could have huge implications on the treatment and survival rates of cancer victims. The researchers, along with scientists in India and Australia have created the world’s first RNA aptamer, a chemical antibody that targets cancer stem cell marker epithelial cell adhesion molecule (EpCAM). This…

Pluripotent stem cell-derived natural killer cells for cancer therapy.

Knorr et al. Transl Res. 2010 Sep;156(3):147-154. Epub Immune therapy of cancer is an exciting prospect given the possibility of treating cancer without the side effects associated with conventional treatments such as chemotherapy or radiotherapy. Additionally, the use of the immune system to target tumors offers the possibility of eradicating micrometastasis, which often cannot be…

Eradication of brain tumor stem cells with an oncolytic adenovirus.

Jiang et al. Discov Med. 2010 Jul;10(50):24-8. Philosophically, tumor cells have an advantage to humans in the “War on Cancer”. That is, the tumors have the ability to rapidly mutate, so that when drugs are given to fight the tumor, the tumor can “mutate around” the drug and become resistant. This occurs in several ways:…

Natural Compound in Broccoli Slows Breast Cancer Stem Cells

The area of cancer stem cells is very hot. To give an example, the pharmaceutical company GSK recently purchased the cancer stem cell company Oncomed for more than a billion dollars, at a time when Oncomed’s cancer stem cell-targeting drugs were not even tested in humans. This area is of great interest because it suggests…

Fat May Serve a Purpose in Stem Cell Research

Scientist Dr. Joseph Wu at the Stanford University School of Medicine has recently published a new and improved method to generate stem cells "artificially".  For almost a decade there has been substantial controversy regarding the use of embryonic stem cells, with the debate becoming socially and politically focused as opposed to based on science: one…