Rare Heart Defect Reproduced in Petri Dish, Hope for Cure

Dr. Ananya Mandal, MD A team of researchers has created beating heart cells in the lab using skin cells of children with a rare heart defect. The team, led by Ricardo Dolmetsch of Stanford University took skin cells from children with Timothy syndrome, a rare heart condition commonly associated with autism, as well as syndactyly…

How Inflammation Suppresses Stem Cell Function

Wang et al. PLoS One;5(12):e14206. Low grade inflammation is well known to correlate with development of numerous disease conditions such as heart failure, kidney failure, and diabetes. It is generally accepted that oxidative stress caused by inflammation is one of the means by which disease evolution occurs. Inflammatory conditions usually generate oxygen free radicals that…

Stem cell therapy benefits patients with chronic heart failure—study

(Neharika Sabharwal) After a heart attack the myocardium (heart muscle) undergoes a period of damage during which cells of the body attempt to heal the injured tissue. This occurs through stem cells found in the heart itself, called cardiac specific stem cells (CSC) as well as bone marrow stem cells which seem to exit the…

Stem Cells Don’t have to be Alive to Be Beneficial

The use of stem cells in patients who have poor circulation is well-known.  In fact, the first use of stem cells for conditions other than blood disorders was in patients who were undergoing bypass surgery.  Usually patients undergo bypass because of advanced atherosclerosis that is inhibiting the flow of blood to the heart muscle.  Despite…

Saginaw stem-cell therapy study breaking new ground

Use of stem cells for treatment of degenerative diseases offers great hope. Unfortunately, this hope is tempered by practical considerations. For example, in patients with heart attacks it is known that readministration of their own stem cells into the infarct related area results in profound improvement http://www.youtube.com/watch?v=flv0RmzPyLU. The problem with this is that stem cells…

Magnetic Attraction of Stem Cells to Injured Heart Creates Potent Treatment

The intracoronary administration of bone marrow stem cells in patients who have suffered a heart attack has been demonstrated to cause beneficial effects in double blind studies, as discussed in this video http://www.youtube.com/watch?v=flv0RmzPyLU. Intracoronary administration has potential side effects since a balloon needs to be expanded in the area where the heart attack occurred, which…

Stem Cell Treatment for Heart Attacks: Timing is Everything

Skeletal myoblasts are a type of muscle-specific stem cell that have been used previously in several clinical trials, particularly for heart failure and post-heart attack patients.  Advantages of this type of stem cell include the fact that they are from adult sources (no risk of cancer), they are already committed to becoming muscle cells, and…

Adult Stem Cells Healing Hearts

Adult stem cells are being more and more used in patients to achieve effects.  In the treatment of patients with heart failure, Dr. David Prentice, discussed two studies in which adult stem cells appear to have some benefit.  The first study was the result of a Brazil-Florida joint effort in which it was discovered that…