Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

Generation of inducible pluripotent stem cells (iPS) offers the possibility of creating patient-specific stem cells with embryonic stem cell therapeutic potential from adult sources.  Recently the main hurdle of iPS cell generation, the need for introduction of oncogenes in the adult cells, has been removed by use of chemical modulators as well as alternative non-cancer…