Allogeneic stem cell transplants in non-conditioned recipients

The current belief that immune suppression is needed for safety and efficacy of cord blood transplants is overcome by this patent application. The teachings of this patent, which have subsequently been published in the Journal of Translational Medicine, include methods of matching a donor with recipient so as to avoid immune mediated rejection, as well as selectively purifying the graft using clinically approved methods so as to allow for maximal stem cell activity without the need for immune suppression. This patent covers some of the technologies in the AngioStem platform.