“I am riding my bike 10 miles a day, swimming, walking…all virtually PAIN FREE!” – Debra Deuble

We received this message from Debra Deuble yesterday. Debra gave us the ok to share it with everyone.

“I am a stem cell recipient from your clinic in Panama! I am grateful every day that I had this done. It has been over a year and I have not been on any medications and I feel great! I am riding my bike 10 miles a day, swimming, walking…all virtually PAIN FREE! I feel like I have had the fountain of youth! I was diagnosed with severe Rheumatoid Arthritis. I was 37 when I had symptoms and 46 when diagnosed. Was on meds for 7 years and nothing helped. So glad I found your website in my search for a cure!!”

Sam Harrell’s Stem Cell Journey: Stem Cell Therapy for Multiple Sclerosis

Sam Harrell sent us this homemade video documenting his progress from 2010 until now (2014). Sam was coaching football at Ennis high school in Texas when MS struck him hard, forcing him to retire. Since then, after several rounds of stem cell therapy at the Stem Cell Institute in Panama, Sam has returned to coaching football, something he though that he would never be able to do again.

For more information about umbilical cord tissue-derived mesenchymal stem cell therapy for MS, please visit: http://www.cellmedicine.com/stem-cell-therapy-for-multiple-sclerosis-3/

Stem cell treatments for spinal cord injury – Jamie Richie discusses her improvements

Jamie Richie discussed her treatments and improvements while undergoing her third round of stem cell therapy at the Stem Cell Institute in Panama City, Panama.

Jamie’s first round of treatment comprised 8 intrathecal (into the spinal fluid) infusions of human umbilical cord tissue-derived mesenchymal stem cells (hUC-MSC); 4 intravenous infusions of hUC-MSC; 2 intrathecal infusions of autologous (their own) bone marrow mononuclear cells (BMMC); 2 intravenous injections of BMMC and 19 physical therapy sessions over the course of one month. Her second round of treatments comprised half the infusions of the first.

My name is Jamie Richie. This is my third treatment here. I was diagnosed with a L-1 injury. That was back in January 1st, 2010.

What symptoms did you have before you came for treatment?

I had no movement from my L-1 level down. As far as my right leg, I couldn’t stand on it at all without a brace. If I had a brace on it I could stand and I could walk and all, with braces; and a more aggressive brace. My pain was very strong. My legs; the circulation was worse in my legs. Their color, they were very purple. I could not walk on a treadmill. I had a hard time walking on uneven ground.

What kind of improvements have you experienced since your first treatment?

I’ve improved. I’ve had like five major things after my very first treatment, which was a year ago in January. I was able to stand on my right leg without a brace and walk. My pain level dropped between a 10 down to a 6. It’s controllable. The circulation in my legs; my balance is better. I can carry things while walking with a walker. I can transfer something from one counter to the next. I can be in my kitchen, hold onto the counter and stand and get out a glass out of the cabinets. I can walk on a treadmill and I am actually able to walk three speeds higher than when I first started walking. So I’ve had great gains there. After my second treatment, I was able to walk even stronger on my right leg. I have better bladder control. I got better bladder control out of the first treatment. And I noticed that I didn’t get a whole lot until about two months after the treatment.

How has this experience changed your life?

This experience has changed my life, just one, the nerve pain. I’m more comfortable driving. I can walk barefoot on my right leg without any braces or… It’s just nice being able to walk barefoot. Being able to get onto the treadmill, that’s huge for me. I don’t have to drive to a park or a track and walk on a track. I can get on the treadmill and keep a good pace and keep better tracking of what my progress is. For my balance, being able to stand and take my clothes out of my washing machine and put them in my dryer to standing in the kitchen and being able to take a pan that has water in it and put it in the sink. I was unable to do any of that. If I were standing, would have to have help. Transferring, you know, something from one counter to the next. Walking on uneven ground is big for a life change. If someone comes to the house to pick me up, walking to the car. To be able to walk into a store, I can go to the grocery store, walk in, get into a power chair and do all my grocery shopping there. So, get back onto the walker and get back into my car. It’s given me more independence, which is very big for me.

What would you say to someone who is considering this treatment?

It’s not going to hurt you to try it. It’s going to hurt you not to try it. If I could suggest anything, I would just say as soon as you’re better from your injury where you are not in any more pain and able to get to therapy, I would go. And I would go as soon as you can. Otherwise, you’re going to sit back and go, “Gee what if I wouldn’t of? What if I had gotten?“ There are a lot of people to talk to. There are people who didn’t gain anything. I have not spoken to anybody who didn’t gain anything off a spinal cord injury. Do your homework. It’s worth it and it doesn’t hurt. I mean, it doesn’t hurt me. I can feel completely my whole back. So when I get the injections in my spine… The anesthesiologist is excellent. The doctor is excellent. I will have close to 20 injections in my back and I have had no bad experiences at all. I’ve had no negative side effects at all, none. I’ve only had positive side effects.

5 year-old autistic boy making steady gains after umbilical cord stem cell treatments

The following is a transcription of an interview with Anju and Selva R. regarding their son Ajay. Ajay was diagnosed Autism Spectrum Disorder (ASD) just before his second birthday in February 2011. Since that time, Ajay has received several courses of human umbilical cord-derived mesenchymal stem cells at the Stem Cell Institute.

“In general, his improvements have been so great that the school is advising a repeat assessment to see if he still fits under the diagnosis of ASD.”

What kind of ASD symptoms did Ajay have before his stem cell treatments?

His symptoms included temper tantrums that resembled seizures lasting 30 to 45 minutes at a time. He was hyperactive and sometimes unintentionally violent in his play. He had very poor eye contact. He did not answer to his name. His dietary habits were very limited.

How has Ajay improved since his last round of treatments?

Thus far, he has had three Rx cycles at the Center: July, 2012 (age 3y-4mo), March 2013 (age 4y) and Feb 2014 (age 4y, 11 mo). Each time he showed rather sudden improvements in almost all areas of prior difficulties. After his first treatment, 90% of the tantrums disappeared within two weeks. His eye contact suddenly improved. He became much more aware of his surroundings – almost as if he just woke from a half sleep state. He started playing with his father for first time and with his twin somewhat. Transitions were much easier. Speech improved. He started greeting his therapists by name each day. We did not tell the therapists of the stem cell Rx as we wanted to get an unbiased feedback on his progress. They were rather surprised at the sudden change in his cognition and behavior. He still had some issues like not initiating play with his twin or other kids. His eye contact was much improved but not quite the same level as expected of his age group. Reciprocal conversation was also limited. After his second Rx he started to initiate play with his sib and other kids. Tantrums completely disappeared. Transition issues and general parental compliance improved. He started attending JK class in Sept 2014. He was assessed by a clinical psychologist for his post IBI evaluation in Oct 2014. Overall, he had showed considerable improvements, especially in non-verbal learning abilities as these were now on par as expected for normal kids his age (45’th percentile). However, his verbal learning abilities remained compromised (8’th percentile). His main limiting factors were his attention span and his diet remained somewhat limited. After his third Rx in Feb 2014, we have thus far noticed remarkable improvement in his diet. He is now eating sometimes even better than his normal twin. His language seems to be further along with more complex sentences. Hyperactivity and focus has also improved and we are only one month post Rx at the time of writing of this feedback. In general, his improvements have been so great that the school is advising a repeat assessment to see if he still fits under the diagnosis of ASD. We are awaiting an appointment for this some time later this year.

What kind of treatments and/or therapies did you try before coming to Panama for stem cell therapy?

Following the diagnosis, we attended parental workshops to help these types of kids with speech and other developmental issues. We began taking him daily to Ontario Early Years centers where Ajay could be exposed to other normal kids his age group so can join in on children’s activities. His speech improved a bit with this exposure. However, he would not play with the other children. Nine months after his diagnosis, he was accepted into the Themes Valley Autism Treatment program. They started sending in IBI therapists to work with Ajay for about 6 hours per weekday. He made a little bit further progress in language but eye contact remained extremely poor. Temper tantrums were still a major issue. Transitions remained very difficult. Diet remained very limited. He did not play with his normal (non-identical) twin or other kids.

How did you find the clinic and what made you decide upon the Stem Cell Institute?

We found the Panama clinic by researching for additional modalities of treatment. We reviewed some of the candid discussions and videos of families of former patients of the clinic. We queried the medical officers at the clinic to ensure cell samples were screened thoroughly for blood borne pathogens. We finally decided to go ahead with the treatment as Ajay clearly would not have had a very happy life if we continued with only behavioral therapy. We also were afraid he may unintentionally harm his normal twin due to his sudden violent movements and outbursts.

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Umbilical cord mesenchymal stem cell therapy for PDD-NOS (Autism spectrum)

The Mendez family discusses their son’s progress following several rounds of stem cell therapy at the Stem Cell Institute. They’ve requested that we not use their first names in order to maintain privacy.

“He is a different child than he was before we started the treatments, and everyone is amazed at how well he is doing. We are grateful to God for helping us to find this treatment because now we can see our son being fully recovered.”

What is your son’s diagnosis?

Our son was diagnosed with severe apraxia, developmental delay, and PDD-NOS

What symptoms did he have before coming for stem cell treatment?

At six years old, he had a very short attention spam and very little speech. He had a lot of constipation and problems with balance and coordination. We were extremely concerned.

What did you try in the US before seeking help outside the country?

We tried everything with our son. He was treated by a DAN Doctor and we did many biomedical treatments. He was doing intense speech therapy and many hours of Hyperbaric Oxygen Therapy, but he still had very little speech and we were very frustrated with the lack of progress.

Why did you choose the Stem Cell Institute?

After doing a lot of research and talking to other parents who had success with Stem Cell treatment for their children, we decided we needed to try. We choose the Stem Cell Institute because we spoke to other parents who had great results and read about their research. We also went to their conference in Texas.

How were the doctors at the clinic?

The doctors at the clinic were very knowledgeable and professional. The clinic was impeccable.

How are your son’s symptoms now?

After our son’s stem cell treatments, he has improved tremendously. He has a great attention span and has gained a ton of speech. He is no longer constipated and the improvements keep coming. We saw huge improvements in just weeks after the stem cell treatments that we never saw with years of Biomedical treatment and speech therapy.

When did you start noticing a difference?

We say improvements just after two weeks.

How has this changed your lives?

This treatment has changed our lives significantly. Our son is able to speak in sentences and express himself. He can sit and eat at a restaurant and has absolutely no problems with attention. He is a different child than he was before we started the treatments, and everyone is amazed at how well he is doing. We are grateful to God for helping us to find this treatment because now we can see our son being fully recovered. We are very thankful to everyone at the Stem Cell Institute for the amazing job they are doing.

The Mendez Family

Neil Riordan PhD on stem cell expansion in stem cell therapy

Stem Cell Pioneers featured Dr. Riordan in its February installment of “Ask the Doctor”, a monthly segment that features stem cell scientists and doctors answering questions from readers about stem cell therapy.

Over the next several days, we will share these questions and Dr. Riordan’s answers with our readers.

Question: Are there some conditions such as neurological ones that respond better when the cells are greatly expanded? Is a high quantity essential for success or is that something that may be more of a selling point at some clinics? I have also seen this advertised for COPD and other conditions. It’s almost like the more cells the better, but I would like your opinion.

Dr. Riordan’s Answer: That really depends on the quality of the cells after expansion. If they are still robust, not senescent, and still have a good secretion profile, then the more the better may be useful up to a point. If you take a small pool of starter cells and expand them to exhaustion, then I don’t think you are going to have a very good product. The MSCs used in Panama are not expanded beyond passage 5—a point at which there is no senescence in the population and they have a robust cytokine secretion profile. In order to use only cells that meet our release criteria, cells from approximately one (1.2 to be exact) out of 10 donated umbilical cords are used.

Contrast that to cells from a patient’s own fat tissue that are expanded. Firstly, the starting cells may, and many times are not very robust—they secrete little or no beneficial cytokines or chemokines, and must be expanded to hilt in order to hit the cell number. Please see my answer to number 7 for more on this subject.

This brings up a slightly different, yet related topic. There has been a lot of talk at recent meetings about more defined endpoints for the cells being used, and I couldn’t agree more. There are MSCs from bone marrow, menstrual blood, fat tissue, umbilical cord (even different parts of the umbilical cord—around the blood vessels, from the Wharton’s jelly, from the subepithelium, from the cord blood itself—which are most likely contaminants from a bruised placenta rather than the blood), teeth, amniotic membrane, amniotic fluid just to name sources in the “we didn’t mess with mother nature” adult stem cell world. Add to that the infinite variables when you consider the age and physical condition of the donor, particularly when using adipose or bone marrow as a source material and we, as a field, could be saying almost anything by using the term, “mesenchymal stem cell.” I think it is time that there is standardization in the field beyond the current definition of expressing/not expressing certain surface markers and the ability to differentiate into fat, bone, and cartilage. That standardization could come from using endpoints such as “remaining proliferative capacity (the number of doublings achievable in culture from the treatment cell bank), the secretome, even if there is standardization of one or two molecules, such as HGF, or one of the prostaglandins.

In the future I believe the field will take it a step further by measuring, even by a surrogate marker, the potential effects of the cells on the target condition. In the case of autoimmunity the cells and their secretions could be tested for their capacity to modulate the immune system. In the case of inflammatory conditions, the cells and their secretions could be tested for the ability to control or block inflammation.

Neil Riordan PhD on Peri-lymphatic Stem Cell Treatment for Multiple Sclerosis

Stem Cell Pioneers featured Dr. Riordan in its February installment of “Ask the Doctor”, a monthly segment that features stem cell scientists and doctors answering questions from readers about stem cell therapy.

Over the next several days, we will share these questions and Dr. Riordan’s answers with our readers.

Question: I have heard from patients that you are doing intralymphatic stem cell injections. I think there are a lot of IntraLymph studies on other things like allergies, but none on stem cells that I can find. What is the reasoning behind this new route of administration? If stem cells get stuck in the lungs and we worry about that, why inject them directly into the lymph system where they would go to the spleen?

Dr. Riordan’s Answer: The goal of our treatments umbilical cord mesenchymal stem cells for patients with multiple sclerosis really has nothing to do with repairing the damaged or destroyed myelin in the lesions found in the brain and spinal cord. Because multiple sclerosis is first and foremost an autoimmune disease our goal is to address the immune dysfunction. At the root of the disease is a pool of immune cells called T-cells, which actively proliferate, cross the blood brain barrier, and attack myelin. Our primary goal then is to interfere with myelin-specific T-cell reproduction (something called “clonal expansion’). Mesenchymal stem cells (MSCs) have been shown in multiple studies to have the capacity to block this so-called clonal expansion of activated T cells. In a way MSCs immunosuppress, but unlike some drugs that suppress the immune system this specific blocking of activated T cells does not quash the entire immune system—the cells and their secretions only block the clonal expansion. Other drugs that suppress the immune system—for example hydrocortisone—have an effect on the entire immune system, which can increase the risk of the recipient to infectious diseases and even some cancers.

If it were the goal of the treatment to induce remyelination then certainly the route of delivery would be of greatest importance. You would want for the cells (or whatever proposed remyelination agent) to be as close to the lesions requiring the repair as possible. So I understand the rationale for the question.

In my opinion it will be difficult to successfully treat multiple sclerosis by remyelination alone because if you do not address the immune problem you will continue to lose myelin. Therefore, getting the cells to the lesions for myelin repair is not particularly important. Further support for this opinion is that there is very good evidence that the body has the innate ability to regenerate myelin without intervention. There are two good examples of this. The first example comes from a condition called Guillain–Barré syndrome. The syndrome is an autoimmune disease that results from an immune attack on the myelin of peripheral nerves. There is an ascending paralysis and the condition can be life threatening if the paralysis gets high enough to affect breathing. It is treatable and generally temporary. In 80% of the patients the underlying nerves are not irreparably damaged and there will be no long-term neurologic symptoms. 20% experience permanent nerve damage because the axons of the nerves are damaged. The good news is that the disease is temporary. The better news is that in the mild cases in which the axons were not destroyed, complete remyelination occurs—the body has the capacity to restore myelin.

The second example comes from a phenomenon seen with serial MRI images of the brains in people with MS. Fifty percent of these low intensity lesions known as “black holes” revert within one month of appearance, indicating that remyelination has occurred spontaneously.

Further support for the “treat the immune system and not the Central Nervous System” in MS comes from the work of several groups, including Northwestern University who are using chemotherapeutic “conditioning”, ie. wiping out the immune system (and the by-standing hematopoietic stem cells) followed by bone marrow reconstitution using previously harvested bone marrow stem cells. There are published results of many cases improving without anything having been done to address the myelin loss.
To the question of intra-lymphatic injections: There has been no work on “intra-lymphatic” injections. We are looking into peri-lymphatic (near the lymph nodes) injections of huMSCs for patients who are refractory to intravenous treatment.
Here is a little background on this subject: Dr. Arnold Caplan of Case Western Reserve, the scientist to first describe mesenchymal stem cells, was in Panama last year consulting with us. He also presented at a conference that we cosponsored. In one of my discussions with Dr. Caplan he casually mentioned that whenever they injected mesenchymal stem cells into the abdominal cavity of animals that did not have an active inflammatory process in there in the cavity the MSC’s would automatically go to the abdominal lymph chains. They were able to determine this because they use cells that were labeled with the florescent probe. I found this very interesting given that the 70-80% of the immune cells of your body reside in the abdominal cavity in and around the intestines.

The rationale for peri-lymphatic treatment is relatively simple. Firstly, the goal of therapy in autoimmune disease is to induce immune tolerance in the face of immune intolerance. The majority of the immune cells are found in the lymphatic (which includes the lamina propria) system of the gut. MCSs will, when lacking a more compelling inflammatory signal, migrate to the lymph nodes. Once in the lymph nodes they will migrate and interact with the immune cells (T-cells and T-cell priming dendritic cells). We know for a fact that MSCs interfere with dendritic cell priming of T-cells.

My book will be coming out in April. It will go into greater detail on this subject and many more. There are case histories as well as treatment protocols and rationale for each condition. Information about how to get the book “Mesenchymal Stem Cells: Nature’s Pharmacy” will be on www.Riordanbooks.com, as well as on www.amazon.com.

Stem cell therapy for autism: Ken Kelley visits Amen clinic in New York

Ken Kelley visits the Amen Clinic in New York following umbilical cord-derived stem cell treatments at the Stem Cell Institute in Panama City, Panama. Ken has shown remarkable improvements. See his before and after qEEGs.

http://www.cellmedicine.com/stem-cell-therapy-for-autism-amazing-qeeg-results-of-kenneth-kelley/

http://www.cellmedicine.com/stem-cell-treatments-for-autism-kenneth-kelley/

http://www.cellmedicine.com/kenneth-kelley-tv-news-story/

Periventricular leukomalacia patient improving after stem cell therapy

Jennifer Mittman just sent us this heartwarming update on her son, Colton who was diagnosed with PVL (periventricular leukomalacia) and spastic diplegia, a form of cerebral palsy. Colton received injections of umbilical cord mesenchymal stem cells over the course of several days in September 2013.

“Update for Colton Mittman. Colton had his first round of stem cell treatments in September of 2013. He has improved so much in this mobility. He is able to move his arms around so much better. Colton has now started walking up and down the stairs with the support of the hand rail. Two days before Christmas he took three steps unassisted. We are so happy we took this journey. We are hoping to make another trip back later this year.”

Before his treatments, Colton could only walk with a walker and was unable to talk.

Hip replacement? Not after stem cell therapy!

Dear Jay, thank you for asking me to share my comments. Unfortunately, I am a very private person, I do not want my name, email or anything else posted on a public forum. You may post the email on your web site, with my name and email redacted (deleted at owner request). Then if a specific person wants to email me that is OK for you to give it to them. I am sorry I cannot be more accommodating. T.C. [redacted]

My over all results are very good, my knee does not hurt (95% less pain) I never wear a knee support any more. My back is also much better (85-90% less pain). My hip, I walk around my apt w/out my cane all the time. (90% less pain). Dr. D. [redacted] told me the main reason to get a hip replacement is due to pain &/or lack of mobility. He said since I experience neither, he would not recommend a hip replacement at this time. Given, that before I started stem cell therapy, I was told I should have had a hip replacement 2 years prior, this is amazing.

So. overall I am very glad I did the treatments.

Thanks, T.C. [redacted]