Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy

IV-Vitamin-CNina Mikirova, Neil Riordan, Joseph Casciari

Med Sci Monit 2016; 22:14-25
DOI: 10.12659/MSM.895368

BACKGROUND: Cytokines play an important role in tumor angiogenesis and inflammation. There is evidence in the literature that high doses of ascorbate can reduce inflammatory cytokine levels in cancer patients. The objective of this study was to investigate the effect of treatment by intravenous vitamin C (IVC) on cytokines and tumor markers.

MATERIAL AND METHODS: With the availability of protein array kits allowing assessment of many cytokines in a single sample, we measured 174 cytokines and additional 54 proteins and tumor markers in 12 cancer patients before and after a series of IVC treatments.

RESULTS: Presented results show for our 12 patients the effect of treatment resulted in normalization of many cytokine levels. Cytokines that were most consistently elevated prior to treatments included M-CSF-R, Leptin, EGF, FGF-6, TNF-α, β, TARC, MCP-1,4, MIP, IL-4, 10, IL-4, and TGF-β. Cytokine levels tended to decrease during the course of treatment. These include mitogens (EGF, Fit-3 ligand, HGF, IGF-1, IL-21R) and chemo-attractants (CTAC, Eotaxin, E-selectin, Lymphotactin, MIP-1, MCP-1, TARC, SDF-1), as well as inflammation and angiogenesis factors (FGF-6, IL-1β, TGF-1).

CONCLUSIONS: We are able to show that average z-scores for several inflammatory and angiogenesis promoting cytokines are positive, indicating that they are higher than averages for healthy controls, and that their levels decreased over the course of treatment. In addition, serum concentrations of tumor markers decreased during the time period of IVC treatment and there were reductions in cMyc and Ras, 2 proteins implicated in being upregulated in cancer.

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Stem Cell Treatments for Autism – Danny Briones

Danny Briones discusses his son’s improvements following *umbilical cord tissue-derived mesenchymal stem cell treatments at the Stem Cell Institute in Panama.

For more information about autism treatment in Panama, please visit: https://www.cellmedicine.com/stem-cell-therapy-for-autism/

*umbilical cord tissue is donated after normal, healthy births

Why Stem Cells Work: Clinical Trials for Spinal Cord Injury, Multiple Sclerosis, Rheumatoid Arthritis, and Duchenne’s Muscular Dystrophy

Neil Riordan, PhD speaks at the Riordan-McKenna Institute and Stem Cell Institute fall seminar in Southlake, Texas on October 10, 2015.

Dr. Riordan discusses:

  • How our lab selects uses specialized screening techniques to select only the stem cells that we know will be the most useful for our patients. Only about 1 in 100 cords pass this screening process.
  • How umbilical cord mesenchymal stem cells (MSC) control inflammation, modulate the immune system and stimulate regeneration.
  • How the number and function of our own stem cells decline over time.
  • How MSC secretions promote healing
  • Where MSCs are found in our body
  • First clinic trial in the US using umbilical cord tissue-derived stem cells
  • How MSC doubling times dramatically decrease as people age, which is why cord cells are much more robust than a patient’s own cells as they age
  • The origin of Medistem Lab in Panama
  • Why the Stem Cell Institute and Medistem Labs are in Panama
  • Stem cell therapy laws and approvals around the world
  • Global interest in mesenchymal stem cell therapy research
  • Current clinical trials using mesenchymal stem cells
  • Clinical trials in Panama
  • Collaborations with corporations and educational institutions
  • Mesenchymal stem cell selection, donor selection, and testing
  • Brief tour of Medistem Panama stem cell laboratory
  • Isolation and production of mesenchymal stem cells
  • Discovery of mesenchymal stem cells in menstrual blood
  • Umbilical cord mesenchymal stem cell studies for rheumatoid arthritis
  • The role of T-regulatory cells in rheumatoid arthritis and multiple sclerosis
  • Treating spinal cord injuries with mesenchymal stem cells
  • Mechanism of mesenchymal stem cells on spinal cord injury. They are not becoming tissue. It’s their secretions that allow the spinal cord to heal itself.
  • Umbilical cord MSC studies on spinal cord injury
  • Data from Stem Cell Institute spinal cord injury patients
  • Video from treated spinal cord injury patients
  • Postnatal MSC safety
  • MSCs and cancer risk – MSCs have been shows to actually inhibit tumor growth

Multiple Sclerosis patient, Sam Harrell has no more use for his walker after stem cell therapy!

Here is an update from Sam Harrell who was speaking at our public seminar in Southlake, Texas in October, 2015. Sam has been to the Stem Cell Institute in Panama several times for umbilical cord mesenchymal stem cell therapy.

The beginning is about as inspirational at it gets! Go Sam!

“I used to need this [walker] get out of the house. Now, it needs me!” – Sam Harrell

Josh’s Journey to the Stem Cell Institute in Panama for Spinal Cord Injury Treatment

Follow Josh’s Blog http://joshsrecovery.blogspot.com

Monday, October 5, 2015

Josh Rivers Weights“Ok these stem cells might really be kicking in now! One of the leg machines I use I have only been able to do 30lbs max, over the last few months of going to the gym 3 times a week. Today all of a sudden I am able to do 70!!!!??? I am really in shock right now to see an increase like this out of nowhere.. just 2 days ago I was struggling with 30!! I was also able to add more weight to 2 out of the other 4 leg machines I use. I can’t believe it!!”

Note: The stem cell treatment protocol Josh underwent included multiple intravenous and intrathecal (into the spinal fluid) injections of umbilical cord tissue-derived mesenchymal stem cells and his own bone marrow-derived mesenchymal stem cells administered over the course of one month. For more information about stem cell therapy for spinal cord injury, visit: https://www.cellmedicine.com/stem-cell-therapy-for-spinal-cord-injury/

After stem cell therapy in Panama, former motocross champ aims for handcycling glory at 2020 Paralympics in Tokyo

Blake Colleton on Bike

By Ashleigh Stevenson Original Story Here

A former up-and-coming motocross champion who broke his back during a crash is aiming to represent Australia at the Tokyo Paralympics in a different sport.

Blake Colleton, 18, from Murwillumbah in northern New South Wales, fell during a motocross race in Victoria last year, resulting in paraplegia from the chest down.

He has taken up handcycling as part of his rehabilitation and is aiming to compete at the 2020 Paralympics in Japan.

Mr Colleton said he did not realise the extent of his injury when it first happened.

“It wasn’t too bad at first and then it sort of hit me a little bit when I was in hospital what actually had happened to myself,” he said.

“I was still happy with life and knew that it was just a change in direction – I just have to move on.

Karren Colleton with son, Blake Colleton

Karren Colleton with son, Blake Colleton

“I need to keep working hard and doing it for myself – not anyone else, just me.

“I was racing motocross professionally before the accident, so it’s just a change in direction for me.

“I definitely want to get to the Paralympics.”

In January, Mr Colleton and his mother Karen travelled to Panama in Central America so he could undergo stem cell treatment.

The therapy involved the intravenous and intrathecal (into the spinal fluid) injection of mesenchymal stem cells from human umbilical cord tissue and his own bone marrow.

The treatment is not available in Australia.

Karen Colleton said they hoped to return to Panama for a second round of treatment later this year.

“He’s got a lot more core muscle and lower back control, which helps so much when you’re a paraplegic,” Ms Colleton said.

“We’re hoping the second lot of treatment will move the injury lower to maybe bring back bladder and bowel function and lower body function.”

What are the sources of the stem cells used at Stem Cell Institute in Panama?

Lately, especially on our Facebook Page many people are asking us, “What is the source of the stem cells?”

Stem cells under fluorescent microscope.At the Stem Cell Institute, we use two types of stem cells. Primarily, we use allogeneic mesenchymal stem cells harvested from human umbilical cord tissue. In addition to allogeneic mesenchymal stem cells, our spinal cord injury protocol uses autologous (patient’s own) stem cells harvested from bone marrow.

Umbilical cord tissue is donated by mothers after normal, healthy births.

All donating mothers are tested for infectious diseases and have their medical histories screened. We obtain proper consent from each family prior to umbilical cord donation.

All mesenchymal stem cells harvested from umbilical cords are screened for infectious diseases to International Blood Bank Standards before they are approved for use in treatments.

A small number of umbilical cords (about 1 in 10) pass our rigorous screening process.

Dr. Riordan on the Umbilical Cord Selection Process at Stem Cell Institute

“Through retrospective analysis of our cases, we’ve identified proteins and genes that allow us to screen several hundred umbilical cord donations to find the ones that we know are most effective. We only use these cells and we call them ‘golden cells’.

We go through a very high throughput screening process to find cells that we know have the best anti-inflammatory activity, the best immune modulating capacity, and the best ability to stimulate regeneration.”

What are the advantages of treating with allogeneic human umbilical cord tissue (HUCT)-derived mesenchymal stem cells?

  • Anyone can be treated since HUCT mesenchymal stem cells are immune system privileged. Human Leukocyte Antigen (HLA) matching is not necessary.
  • The stem cells with the best anti-inflammatory activity, immune modulating capacity, and ability to stimulate regeneration can be screened and selected.
  • Allogeneic stem cells can be administered multiple times over the course of days in uniform dosages that contain high cell counts.
  • Umbilical cord tissue provides an abundant supply of mesenchymal stem cells.
  • No need to collect stem cells through invasive procedures such as liposuction or bone marrow collection
  • There is a growing body of evidence showing that mesenchymal stem cells from umbilical cords are more robust than mesenchymal stem cells from other sources such as fat.

The body’s immune system is unable to recognize human umbilical cord tissue (HUCT)-derived mesenchmyal stem cells as foreign and therefore they are not rejected. HUCT stem cells have been administered thousands of times at the Stem Cell Institute and there has never been a single instance rejection (graft vs. host disease). Umbilical cord-derived mesenchymal stem cells also proliferate/differentiate more efficiently than “older” cells, such as those found in the fat and therefore, they are considered to be more “potent”.

Watch Professor Arnold Caplan from Case Western Reserve University explain how this works.

Stem Cell Therapy for Autism – “We also had SPECT scans done before and after treatment and the brain changes were noticeable!”

Sondra Lee Facebook

My son underwent his first treatment in March of this year (he has autism and is verbal) and he absolutely LOVED it! He totally knew it was helping him. Each day he would walk in and wait for the doctor to receive his stem cells. We are planning a second trip this fall.

We noticed changes immediately but it can take some time as the body accepts the stem cells and adapts. His long-standing gut issues are gone. We also had SPECT scans done before and after treatment and the brain changes were noticeable! Much of the scalloping that had been present was gone.

If I didn’t think it was helpful I wouldn’t bother going back. The people of Panama are very kind, we felt totally safe, the clinic was impeccable and the staff was helpful and friendly.

Stem Cell Treatments for Autism – “Oh my god the speech!!! He’s TALKING I mean real speech and conversation!!! Today was crazy!!!”

This new facebook update on Anthony Guerriero says it all:

Autism Stem Cell Patient Anthony Guerriero

“Oh my god the speech!!! He’s TALKING I mean real speech and conversation!!! Today was crazy!!! Anthony was TELLING us all about his birthday, what he wants to do, counting down the days, what presents he wants, what he wants from Santa vs his birthday, all about Halloween and what each of us is going to be (Mommy is Blue toad, Bella is princess peach, daddy is luigi and Anthony now wants to be Mario), telling us what all the costumes are and what he’s wearing, what he did in school today, what he’s doing tomorrow for his last day, what he wants to play with and with who, what he wants for dinner (tried a new food too), how many days til we go to Maine, what we’re going to do there!!!!!! And on and on. Crazy crazy crazy!!! All spontaneous!!! All TALKING !!! It’s happening big time!!!!! WOW!!!”

Anthony Guerriero FB Comments 8-4-15

Anthony Guerriero FB Comments 8-4-15

Visit Anthony’s Facebook Page Here

Read original news story about Anthony here: Autistic Woodbridge boy making strides after stem cell treatment in Panama

Bixby family raises money for son with cerebral palsy to receive second round of stem cell therapy

Stem Cell Recipient Easton WallaceBIXBY, Okla. – A Bixby family has new hope for their three- year-old son with cerebral palsy. Easton Wallace went to Panama last year to receive stem cell therapy. Unfortunately, the therapy is not FDA-approved in the United States.

The Wallace family held everything from spaghetti dinners to golf tournaments to raise the money for their son’s first treatment. His mother believes it was worth it. She says Easton is learning to talk and gain upper body strength. That is why she is hoping to raise enough money for a second treatment.

“He’s the happiest little boy ever. He can make anyone smile. He’s always smiling,” says Cassie Wallace.

Easton Wallace is a typical toddler. He loves playing outdoors and spending time with family. But unlike most other kids, Easton is living with spastic quadriplegic cerebral palsy, which affects every aspect of his life.

“He can’t sit unattended. He can stand up. He can’t crawl or walk or anything like that,” says Cassie. “He has trouble with his fine motor skills, eating.”

It’s hard for Cassie to watch her son struggle. But she says Easton’s infectious smile and loving personality give her strength.

She told 2 Works for You, “I try to be positive. We are just trying to everything we can for him to give him the best life possible. He has such a positive attitude. He’s so happy and determined. So I think that makes it easier.”

Cassie says a big part of giving Easton the best life possible, is taking him to Panama to receive Stem Cell therapy. She says the $20,000 treatment is not covered by insurance.

Easton’s first treatment was last December. Cassie say it’s working

“He’s repeating everything. He’s putting more words together. It’s really been helping.”

Cassie showed 2 Works for You video of Easton pushing himself in a device called a “pacer” for the very first time. She says this was a big day for their family because they never know for sure what milestones their child will get to experience. That’s why she and her family are trying to raise enough money to cover the expenses for another trip to Panama in December of this year.

The family is organizing another golf tournament in Sapulpa on August 29 at Clary Fields Golf Club. The event is called the “Easton Open.” There is still time to sign up by calling 918-248-4080.

You can also donate directly to the cause by logging on to Easton’s give forward page here.

Original Story and Video on KJRH Tulsa Website