Stem Cell Therapy for Autoimmune Diseases 2017-07-21T21:59:56+00:00
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Stem Cell Therapy for Autoimmune Diseases

What is Autoimmune Diseases?

Autoimmune diseases are conditions in which the patient’s immune system generates cellular and antibody responses to substances and tissues normally present in the body. This might be restricted to one organ or involve a particular tissue in different places. As a result of this immune response, damage to different organs occurs. Examples of autoimmune diseases that have responded to stem cell therapy either in animals or humans include rheumatoid arthritis, multiple sclerosis, and lupus.

How can stem cells help treat autoimmune diseases?

Currently, autoimmune conditions are treated with immune suppressive agents such as steroids, methothrexate, cyclosporine, gold, and more recently infliximab (Remicade). Despite inducing temporary improvement, these approaches possess the possibility of long-term adverse effects, as well as need for life-long treatment.

Stem cell therapy has been demonstrated to induce profound healing activity in animals with various forms of autoimmune disorders. Besides healing damaged tissues, stem cells have the unique ability to modulate the immune system so as to shut off pathological responses while preserving its ability to fight off disease. Stem cells and specifically, mesenchymal stem cells home to inflamed tissue and start producing anti-inflammatory agents. These mediators act locally and do not suppress the immune response of the patient’s whole body. Additionally, mesenchymal stem cells induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack.

Which types of stem cells are used to treat autoimmune diseases and how are they collected?

The adult stem cells used to treat autoimmune diseases at the Stem Cell Institute come from human umbilical cord tissue (allogeneic mesenchymal). These stem cells are expanded at Medistem Panama’s state-of-the-art laboratory.

The mesenchymal stem cells we use are recovered from donated umbilical cords following normal, healthy births. Each mother has her medical history screened and is tested for infectious diseases. Proper consent is received from each family prior to donation.

All umbilical cord-derived stem cells are screened for infectious diseases to International Blood Bank Standards before they are cleared for use in patients.

Only a small percentage of donated umbilical cords pass our rigorous screening process.

Dr. Riordan on the Umbilical Cord Selection Process at Stem Cell Institute

“Through retrospective analysis of our cases, we’ve identified proteins and genes that allow us to screen several hundred umbilical cord donations to find the ones that we know are most effective. We only use these cells and we call them ‘golden cells’.

We go through a very high throughput screening process to find cells that we know have the best anti-inflammatory activity, the best immune modulating capacity, and the best ability to stimulate regeneration.”

What are the advantages of treating autoimmune diseases with allogeneic umbilical cord tissue-derived stem cells?

  • Since HUCT mesenchymal stem cells are immune system privileged, cell rejection is not an issue and Human Leukocyte Antigen (HLA) matching is not necessary.

  • The stem cells with the best anti-inflammatory activity, immune modulating capacity, and ability to stimulate regeneration can be screened and selected.

  • Allogeneic stem cells can be administered multiple times over the course of days in uniform dosages that contain high cell counts.

  • Umbilical cord tissue provides an abundant supply of mesenchymal stem cells.

  • No need to collect stem cells from the patient’s hip bone or fat under anesthesia, which especially for small children and their parents, can be an unpleasant ordeal.

  • There is a growing body of evidence showing that umbilical cord-derived mesenchymal stem cells are more robust than mesenchymal stem cells from other sources.

  • No need to administer chemotherapy drugs like Granulocyte-colony stimulating factor (G-CSF or GCSF) to stimulate the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.

Our mesenchymal stem cells and the US FDA: Are they approved?

Human umbilical cord tissue-derived mesenchymal stem cells (MSCs) that were isolated and grown in our laboratory in Panama to create master cell banks are currently being used in the United States under US FDA regulation.

These cells serve as the starting material for cellular products used in MSC clinical trials for two Duchenne’s muscular dystrophy patients under US FDA’s designation of Investigational New Drug (IND) for single patient compassionate use. (IND 16026 DMD Single Patient).

Will the patient reject this type of stem cell?

The body’s immune system is unable to recognize umbilical cord-derived mesenchymal stem cells as foreign and therefore they are not rejected. HUCT stem cells have been administered thousands of times at the Stem Cell Institute and there has never been a single instance rejection (graft vs. host disease).  As a matter of fact, allogeneic (not the patient’s own) mesenchymal stem cells are approved to treat graft vs. host disease in Canada and New Zealand.

Umbilical cord-derived mesenchymal stem cells also proliferate/differentiate more efficiently than “older” cells, such as those found in the fat and therefore, they are considered to be more “potent”.

In the words of an expert:

In this next video (just past the 1 minute mark), Arnold Caplan, PhD explains the mechanism by which donor mesenchymal stem cells shield themselves from the recipient’s immune system. Dr. Caplan is the scientist who discovered the mesenchymal stem cell. He is commonly referred to as “the father of the mesenchymal stem cell”.

How are the stem cells administered for autoimmune disease treatment?

They are typically given intravenously (IV) over the course of a few days.

Stem Cell Treatment: Autoimmune disease *Protocols

Treatment protocol will be assigned by staff physicians after the patient has submitted all requested medical information and received approval. A patient’s recommended protocol may differ from the example given below.

  • Treatment duration: 4 days and 5 nights

  • Physical examination and blood testing: Monday

  • 6 IV injections of expanded allogeneic (low-passage) mesenchymal stem cells

  • Stem-kine supplement for 1 month (only after medical evaluation in Panama)

*Includes Hilton hotel room with breakfast, WIFI, transportation from and to the airport with VIP airport gate service and expedited customs clearance upon arrival, and transportation between the Hilton and Stem Cell Institute.

Will someone from the Stem Cell Institute be following up with me after I return home?

Our medical staff will be contacting you at regular intervals to see how you are doing. Periodic follow-up also helps us evaluate overall treatment efficacy. Therefore, our medical staff will follow up with you after 1 month, 3 months, 6 months, and 1 year.

May I speak with any successfully treated autoimmune disease patients?

If a person with your specific autoimmune condition has agreed to be a patient volunteer, then yes, you may. Once you have been evaluated and approved for treatment, your patient coordinator will be happy to put you in touch with them.

How do I request more information?

You may contact us by telephone 1 (800) 980-STEM (toll-free in US) and 1 (954) 358-3382.

Apply for treatment today

To apply for stem cell treatment, please complete this Patient Application Form.

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If you would like our doctors to evaluate you and make a recommendation, the first step is to complete our online medical history/application. Once we receive it, our staff will contact you to answer general questions and to guide you through the rest of the evaluation process. This evaluation is free of charge.

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Read Dr. Riordan’s new book about stem cell therapy today

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Stem cells are the repair cells of your body. When there aren’t enough of them, or they aren’t working properly, chronic diseases can manifest and persist.

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