Stem Cell Related Patent Number US7132282

Genetic modification of C57 mice

He, Wei; South Setauket, NY, United States of America
Weng, Wei; Patchogue, NY, United States of America

This invention introduces a new germline-competent black B6 ES cell line from the C57BL/6 mouse strain comprising IC1 or the white albino B6 line from the C57BL/6J-Tyrc-23 mouse strain comprising IAC1. Both genetically modified C57 strains relate to blastocyst-derived mouse embryonic stem cell lines such as IC1, IC2, IAC1, IAC2, IAC3, IAC4, IAC5, IAC6, IAC7 or the IAC8 ES cell line. Further disclosed herein are methods by which such models of C57 mice may be useful in the identification of chimerism in transgenic chimeras which cannot be identified by coat color alone.

Application Number: US2004000768350

Date Filed: 01/30/04

Dated Published: 11/07/06

Assignee: Ingenious Targeting Inc., Stony Brook, NY, United States of America