Stem Cell Related Patent Number US7101708

Hematopoietic cell composition for use in transplantation

Lapidot, Tsvee; Nes-Ziona, Israel
Peled, Amnon; Tel-Aviv, Israel

This invention describes a novel composition comprised of a mammalian hematopoietic stem and progenitor cell expressing the chemokine receptor CXCR4+, and uses thereof. The composition described herein consists essentially of mammalian hematopoietic CD38?-/low CXCR4+ stem and progenitor cells and has been shown to exhibit a migrating response to stromal-derived factor 1 (SDF-1). Properties by which it is capable of adhering to stromal cells in response to an adhesion-inducing agent are further described. Methods are provided by which hematopoietic CXCR4-/low stem and progenitor cells can be converted into CXCR4+ cells by stimulation with a suitable agent. Therapeutic applications in clinical transplantation are included.

Application Number: US1999000744654

Date Filed: 07/20/99

Dated Published: 09/05/06

Assignee: Yeda Research and Development Co. Ltd., Rehovot, Israel