Stem Cell Related Patent Number US7037900

Composition and method for treating graft-versus-host disease

DiMartino, Jorge; San Carlos, CA, United States of America
Nelson, John Tippett; Danville, CA, United States of America

This invention describes compositions and methods for the prevention and clinical treatment of various forms of graft-versus-host disease (GVHD). Such methods primarily employ inhibitors of adenosine deaminase (ADA). Various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug. This method therefore reduces the risk of developing graft-versus-host disease in a human patient who is a recipient of an organ or tissue transplant.

Application Number: US2001000976468

Date Filed: 10/12/01

Dated Published: 05/02/06

Assignee: SuperGen, Inc., Dublin, CA, United States of America