Stem Cell Related Patent Number US6713610

Human antibodies derived from immunized xenomice

Kucherlapati, Raju; Darien, CT
Jakobovits, Aya; Menlo Park, CA
Brenner, Daniel G.; Redwood City, CA
Capon, Daniel J.; Hillsborough, CA
Klapholz, Sue; Stanford, CA

This invention describes a new human IgG2 monoclonal antibody and an antigen binding portion which specifically binds IL-8. Human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof. Disclosed herein is an isolated antibody or antigen-binding portion which specifically binds IL-8, such that the heavy chain comprises an amino acid sequence encoded by a nucleic acid sequence that has been specifically selected. Such sequences are fully described, as are potential therapeutic uses in the treatment of tumor metastasis, pulmonary edema, asthma, inflammatory bowel disease, and ischemic disease such as myocardial infarction.

Application Number: US2000000614092

Date Filed: 07/11/00

Dated Published: 03/30/04

Assignee: None