Stem Cell Related Patent Number US6365404

Hematopoietic cell method for treatment of HIV infection

O’Donnell, Jr., Francis E.; St. Louis, MO, USA

Described herein are methods of reducing human immunodeficiency virus replication in vivo by the administration to a patient of modified T cells which have been rendered incapable of hosting viral replication. This invention addresses the problem of drug resistance in HIV infection, and methods are introduced for reducing such drug resistance by suppression of the viral load using novel hematopoietic cells. Namely, modified CD4 lymphocyte host cells are used to