Stem Cell Related Patent Number US7101704

Antigen presenting mesenchymal stem cells

Mosca, Joseph; Ellicott City, MD, United States of America

Described herein is a novel composition comprising an antigen-presenting mesenchymal stem cell of the adipocyte lineage and which expresses at least one co-stimulatory molecule. The mesenchymal stem cell described herein has been modified to have at least one exogenous antigen bound to at least one primary surface molecule such that at least one antigen can initiate an immune response while also expressing at least one co-stimulatory molecule. The antigen is described as preferably being a protein, a polypeptide, a lipid or a glycolipid, with a primary surface molecule of MHC I, MHC II or CD1. Further described is a method by which the mesenchymal stem cell may be contacted with interferon-gamma, and methods by which the state of activation of a T lymphocyte population may be determined. Applications for the treatment and prevention of various diseases are described, utilizing the immune response elicited by the antigen described herein.

Application Number: US2000000638358

Date Filed: 08/15/00

Dated Published: 09/05/06

Assignee: Osiris Therapeutics, Inc., Baltimore, MD, United States of America