Stem Cell Related Patent Number US6165785

Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications

Ogle, Cora K.; Cincinnatti, OH, USA
Valente, John F.; Cincinnatti, OH, USA
Alexander, J. Wesley; Cincinnatti, OH, USA

Described herein are methods of producing an immune system suppressor and cell stimulator. The invention relates to a therapeutic process incorporating immune system suppressor cells and immune system stimulator cells from a combination of stem cells and lymphoid-derived cells to which a lipopolysaccharide is added as well as a factor selected from the group consisting of a granulocyte macrophage-colony stimulating factor, a macrophage colony stimulating factor, and a granulocyte-colony stimulating factor. Methods of administering such immune system suppressor and stimulator cells from the co-culture into a host are provided. Therapeutic applications are included, such as in the promotion of allograft survival via the co-culturing of stems cells with lymphoid-derived cells.

Application Number: US1998000178045

Date Filed: 10/23/98

Dated Published: 12/26/00

Assignee: University of Cincinnati, Cincinnati, OH, USA
Shriners Hospitals for Children, Tampa, FL, USA