Stem Cell Related Patent Number US6355476

Nucleic acid encoding MIP-1?a Lymphokine

Kwon, Byoung Se; Carmel, IN, USA

Described herein is a novel isolated and purified cDNA designated L25G25B encoding the mouse lymphokine macrophage inflammatory protein 1 alpha, methods and uses thereof. The invention relates to the full-length isolated and sequenced cDNAs, L2G25B and 4-1BB, such that the cDNA L2G25B encodes for the lymphokine macrophage inflammatory protein-1?a or MIP-1?a, and the cDNA clone 4-1BB is described as an inducible receptor-like sequence found in both cytolytic and helper T-cells. Properties of MIP-1?a and MIP-? include their ability to modulate early myeloid progenitor cell proliferation, while recombinant proteins have been produced for the cytokine, L2G25BP. Therapeutic applications include the myelosuppressive activity of rmuMIP-1?a in vivo.

Application Number: US1992000922996

Date Filed: 07/30/92

Dated Published: 03/12/02

Assignee: Advanced Research and TechnologyInc, Indianapolis, IN, USA