Stem Cell Related Patent Number US6162427

Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization

Baumann, Matthias; Karl-Ludwig-Strasse, Germany
Ochlich, Peter-Paul; Wallonenstrasse, Germany

Described herein is a granulocyte colony stimulating factor (G-CSF) and chemotherapeutic agents, methods and uses thereof. The invention introduces a G-CSF in combination with a chemotherapeutic agent such as cyclophosphamide and methods of producing a pharmaceutical preparation thereof. Further disclosed are techniques by which such a pharmaceutical preparation may be used to boost the mobilization of hematopoietic stem cells from bone marrow in the therapeutic treatment of diseases requiring peripheral stem cell transplantation, thereby resulting in increased efficiency of leukapheresis before myeloblative or myelotoxic therapy.

Application Number: US1998000091401

Date Filed: 11/12/98

Dated Published: 12/19/00

Assignee: Roche Diagnostics GmbH, Mannheim, Germany