Stem Cell Related Patent Number US5843438
Peripheralization of hematopoietic stem cells
Papayannopoulou, Thalia; Seattle, WA, USA
This invention describes a method of peripheralizing CD34+ hematopoietic stem cells in vivo via the administering of an anti-VLA-4 antibody or an anti-VCAM-1 antibody which blocks the binding of VLA-4 antigen on the surface of the CD34+ cells to VCAM or fibronectin. Also disclosed are methods of in vivo peripheralization of the CD34+ cells by administering anti-VLA-4 antibodies or anti-VCAM-1 antibodies.
Application Number: US1995000436339
Date Filed: 07/13/95
Dated Published: 12/01/98
Assignee: Board of Regents University of Washington, Seattle, WA, USA