Stem Cell Related Patent Number US7030292

Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same

Yan, Wen Liang; Potomac, MD, United States of America
Huang, Steve Chien-Wen; Germantown, MD, United States of America
Nguyen, Minh-Thanh; Rockville, MD, United States of America
Lin, Huan (Helen); N. Potomac, MD, United States of America
Lei, Jingqi; Gaithersburg, MD, United States of America
Khanna, Ruchi; Germantown, MD, United States of America

This invention describes a method of producing homozygous stem (HS) cells having a preselected target genotype and/or immunotype from non-fertilized post-meiosis I diploid germ cells. The invention relates to methods for using such histocompatible HS stem cells for prophylactic and therapeutic intervention including, but not limited to, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries and cancer. Further described herein are methods of cataloging a transplant depository of HS cells derived from multiple donors, each of the HS cells being homozygous for a unique HLA haplotype, for the purpose of having a constant, reliable, comprehensive supply of immunohistocompatible cells for diagnostic, therapeutic and transplantation applications.

Application Number: US2002000032495

Date Filed: 01/02/02

Dated Published: 04/18/06

Assignee: Stemron, Inc., Myersville, MD, United States of America