Stem Cell Related Patent Number US6348446

Method for selectively purging CD77+ cells from bone marrow or peripheral blood

Gariepy, Jean; Toronto, Ontario, Canada

Described herein are methods of selectively purging CD77 cells from bone marrow or peripheral blood via the treatment of bone marrow or a blood sample with the shiga toxin or a shiga-like toxin-1. The invention relates to a method for the selective purging ex vivo of CD77 positive cells from bone marrow or peripheral blood containing stem cells prior to autologous transplantation, such that the bone marrow or blood sample is treated with the shiga toxin or a shiga-like toxin-1, which selectively binds to and kills the CD77+ cells or allows them to be removed by affinity chromatography. Therapeutic applications in the treatment of non-Hodgkin’s lymphomas, myelomas and breast cancers expressing CD77 are included.

Application Number: US1998000126995

Date Filed: 07/31/98

Dated Published: 02/19/02

Assignee: None