Stem Cell Related Patent Number US6146623

In vitro-derived genetically altered human neutrophil precursor cells and methods for administering the same

Bender, James G.; Lindenhurst, IL, USA
Maples, Phillip B.; Waukegan, IL, USA
Smith, Stephen; Arlington Heights, IL, USA
Unverzagt, Kristen L.; Palatine, IL, USA
Van Epps, Dennis E.; Cary, IL, USA

Described herein are compositions containing human neutrophil precursor cells with a high content of myeloblasts and pro-myelocytes, methods and uses thereof. The invention relates to genetically altered human neutrophil precursor cells with a cellular component containing approximately 16% human myeloblasts and promyelocytes which have been derived from neutrophil progenitor cells obtained from peripheral blood, bone marrow or cord blood, and less than approximately 5% colony forming units (CFU) of at least 50 cells. Multiple embodiments of the invention are provided. Therapeutic applications in the treatment of genetic or acquired neutropenia are included.

Application Number: US1995000485579

Date Filed: 06/07/95

Dated Published: 11/14/00

Assignee: Nexell Therapeutics Inc., Irvine, CA, USA