Stem Cell Related Patent Number US6043348

Antibody recognizing a small subset of human hematopoietic cells

Lawman, Michael J. P.; Gainesville, FL, USA
Lawman, Patricia; Gainesville, FL, USA

Described herein is a novel antibody specific for an antigen on a subset of primitive hematopoietic cells, methods and uses thereof. The invention relates to an antibody that has binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells. Specific properties of the monoclonal antibody, MG1, are disclosed, as are methods by which it may be used in isolating cell suspensions from human blood and marrow. Therapeutic applications are included for the diagnosis and treatment of leukemia, for bone marrow reconstitution and for various uses in gene therapy.

Application Number: US1997000970032

Date Filed: 11/13/97

Dated Published: 03/28/00

Assignee: None