Stem Cell Related Patent Number US7129072

Crystal of fibroblast growth factor receptor 1 in complex with fibroblast growth factor

Schlessinger, Joseph; New York, NY, United States of America
Hubbard, Stevan R.; Riverside, NY, United States of America
Mohammadi, Moosa; Scarsdale, NY, United States of America
Plotnikov, Alexander; Emeryville, CA, United States of America
Zhang, Zhongtao; Haworth, NJ, United States of America
Kong, Xiang-Peng; New York, NY, United States of America

This invention describes a crystal comprising a purified polypeptide which includes an extracellular domain of the receptor protein tyrosine kinase (RPTK) either alone or in complex with ligands. Further disclosed are properties of the tetragonal space group symmetry and unit cell dimensions. Methods of determination and use are also included for such three dimensional structures of the receptor protein tyrosine kinases and/or their ligands, such as in the design and identification of RPTK modulators, which are useful in the treatment of diseases that are mediated by inappropriate RPTK activity.

Application Number: US2000000049429

Date Filed: 08/30/00

Dated Published: 10/31/06

Assignee: New York University, New York, NY, United States of America