Stem Cell Related Patent Number US7119071

Amino terminal substance P compositions and methods for using the same

Rameshwar, Pranela; Maplewood, NJ, United States of America

This invention describes a new substance-P tetrapeptide, SP(1-4) polynucleotide and encoded polypeptide, and uses thereof. Disclosed herein are methods by which the degradation of SP to SP(1-4) by endogenous NEP in bone marrow stroma can offer mediation of hematopoietic stimulation by stem cell factor (SCF), thereby inducing the production of TGF-beta and TNF-alpha in bone marrow stroma. Further described are compositions containing the SP(1-4) polypeptide, or NEP genetic elements, and applications to slowing the rapid growth of stem and progenitor cells, thereby affording protection from the deleterious effects of cancer therapy. The authors include applications of these polynucleotides and proteins to the alleviation of the toxic effects of chemotherapy and radiation treatment, as well as therapeutic applications of compositions containing NEP antisense sequences and antibodies in the increased proliferation and differentiation of stem and/or progenitor cells in patients receiving conventional chemo- and radiotherapy.

Application Number: US2002000154332

Date Filed: 05/21/02

Dated Published: 10/10/06

Assignee: University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, United States of America