Stem Cell Related Patent Number US7026292

Compositions and therapeutic methods using morphogenic proteins and stimulatory factors

Lee, John C.; San Antonio, TX, United States of America
Yeh, Lee-Chuan C.; San Antonio, TX, United States of America

Described herein are methods for increasing tissue formation with a mixture of morphogenic protein and a stimulatory factor. The invention relates to pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Further disclosed are methods for improving the tissue inductive activity of a morphogenic protein in a mammal using such compositions. Implantable morphogenic devices are described, which consist of a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Further disclosed are methods for inducing local tissue formation from a progenitor cell in a mammal using those devices, and for accelerating allograft repair in a mammal using such morphogenic devices. Also described is a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting the in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Therapeutic applications are provided in the pharmaceutical treatment of mammalian tissue degenerative conditions, and in the repair of bone or cartilage defects.

Application Number: US1999000287500

Date Filed: 04/07/99

Dated Published: 04/11/06

Assignee: Stryker Corporation, Kalamazoo, MI, United States of America