Stem Cell Related Patent Number US6348444

Human growth hormone to stimulate hematopoiesis and immune reconstitution after hematopoietic stem cell transplantation in humans

Chappel, Scott C.; Milton, MA, USA

Described herein are novel uses of human growth hormone for the stimulation of hematopoiesis and immune reconstitution. The invention relates to the use of human growth hormone for the manufacture of a medicament for stimulating hematopoiesis and immune reconstitution when administered to a patient approximately 30 days after transplantation of hematopoietic stem cells. Further disclosed are methods for producing a pharmaceutical composition comprised of a pharmaceutically acceptable carrier, excipient, stabilizer or auxiliary agent, and an effective amount of the human growth hormone of SEQ ID NO:1 or a fragment, analog, variant or chemical derivative thereof. Therapeutic applications include the prevention of graft rejection.

Application Number: US1999000465461

Date Filed: 12/17/99

Dated Published: 02/19/02

Assignee: Applied Research Systems ARS Holding N.V., Curacao, Netherlands