Stem Cell Related Patent Number US6331612
Bone morphogenic protein-16 (BMP-16) compositions
Celeste, Anthony J.; Hudson, MA, USA
Murray, Beth L.; Arlington, MA, USA
Described herein is a novel isolated bone morphogenetic protein-16, and its uses in the development of products for inducing the formation of bone, cartilage and other connective tissue. The invention relates to purified BMP-16 proteins and the DNA molecules encoding the BMP-16 proteins. Therapeutic applications include treatment for the repair of tissue in bone, cartilage, and other connective tissue defects and disorders including those related to tissue of the epidermis, nerve, muscle and organs such as lung, hepatic, cardiac, pancreatic and renal tissue. Also provided are applications of such proteins to the induction of growth and differentiation of undifferentiated embryonic and stem cells.
Application Number: US1999000328775
Date Filed: 06/09/99
Dated Published: 12/18/01
Assignee: Genetics Institute, Inc., Cambridge, MA, USA