Stem Cell Related Patent Number US6291210

Differentiation inhibitor

Sakano, Seiji; Shizuoka, Japan
Itoh, Akira; Shizuoka, Japan

This invention introduces human serrate-2 gene expression products, methods and uses thereof. Described herein is a novel human serrate-2 polypeptide consisting of a polypeptide capable of regulating the differentiation of undifferentiated cells from stem cells. Specific amino acid sequences are provided, as are genetic properties as well as the antibodies specifically recognizing the polypeptide, and methods of their production. Therapeutic applications include the regulation of stem cell differentiation in the treatment of a variety of neoplasms, such as leukemia.

Application Number: US1999000214278

Date Filed: 01/26/99

Dated Published: 09/18/01

Assignee: Asahi Kasei Kabushiki Kaisha, Osaka, Japan