Stem Cell Related Patent Number US6221359

Hemopoietic stem cell multiplier

Komiyama, Atsushi; Matsumoto, Japan
Nakahata, Tatsutoshi; Matsumoto, Japan
Kubo, Tetsuo; Matsumoto, Japan
Tanaka, Ryuhei; Tsu, Japan
Kawano, Genji; Kamakura, Japan
Sudo, Tetsuo; Kamakura, Japan
Sano, Emiko; Yokohama, Japan
Kojima, Katsuaki; Yokohama, Japan

Described herein is a hematopoietic stem cell multiplier comprised of IL-3 and IL-7, methods and uses thereof. The invention relates to a hemopoietic stem cell augmenting agent in which at least one type of hepatocyte growth factor is contained as an active component, such that the hepatocyte growth factor is derived from human normal fibroblasts and may be obtained by genetic recombination techniques. Claims of the invention include an augmenting activity which the hepatocyte growth factor has on undifferentiated pluripotent hemopoietic stem cells, such that the growth factor may be used as a hemopoietic stem cell augmenting agent in the therapeutic treatment of bone marrow suppression, for the treatment of bone marrow disorders and for the in vitro growth of peripheral blood stem cells and bone marrow stem cells.

Application Number: US1993000030410

Date Filed: 05/21/93

Dated Published: 04/24/01

Assignee: Toray Industries, Inc., Tokyo, Japan