Stem Cell Related Patent Number US6136952

Human jagged polypeptide, encoding nucleic acids and methods of use

Li, Linheng; Seattle, WA, USA

Described herein is a novel JAGGED peptide and methods of its use in inhibiting the differentiation of progenitor cells and in the maintenance of such cells in an undifferentiated state. The invention relates to an isolated JAGGED peptide having no more than 40 amino acids, specific sequences of which are provided. Further disclosed are methods by which an Alagille Syndrome disease-associated mutation linked to a JAGGED locus may be detected. Therapeutic applications in hematopoietic reconstitution are included.

Application Number: US1997000882046

Date Filed: 06/25/97

Dated Published: 10/24/00

Assignee: University of Washington, Seattle, WA, USA