Stem Cell Related Patent Number US6107457

Bcr-Abl directed compositions and uses for inhibiting Philadelphia chromosome stimulated cell growth

Arlinghaus, Ralph B.; Bellaire, TX, USA
Liu, Jiaxin; Bellaire, TX, USA
Lu, Dai; Houston, TX, USA
Lopez-Berestein, Gabriel; Bellaire, TX, USA

Described herein are peptide fragments of Bcr-Abl with tyrosine residues, methods of their phosphorylation, and applications thereof. The invention relates to methods by which bone marrow may be processed by the peptide and polypeptide compositions disclosed herein. Therapeutic applications of such compositions are included, such as in the enrichment of bone marrow stem cells for the detection of Philadelphia chromosome-negative cells prior to transplantation, especially as part of autologous bone marrow transplant therapy in the treatment of leukemia.

Application Number: US1995000390353

Date Filed: 02/16/95

Dated Published: 08/22/00

Assignee: Board of Regents, The University of Texas System, Austin, TX, USA