Stem Cell Related Patent Number US6090782

Hemoglobin alpha and beta chain peptide fragments useful for inhibiting stem cell proliferation

Tsyrlova, Irena; Gaithersburg, MD, USA
Wolpe, Stephen D.; Rockville, MD, USA

Described herein are inhibitors of stem cell proliferation, methods and uses thereof. The invention relates to a process by which hemoglobin chains are utilized in the isolation and use of stem cell inhibiting factors which may then be used in the regulation of the abnormal stem cell cycle and for the acceleration of post-chemotherapy peripheral blood cell recovery. Specific amino acid sequences and their residues are disclosed. Therapeutic applications include the protection of mammalian stem cells from antiviral agents and for use in the treatment of cancer and in the maintenance of mammalian hematopoietic stem cells ex vivo.

Application Number: US1998000005546

Date Filed: 01/12/98

Dated Published: 07/18/00

Assignee: Pro-Neuron, Inc., Gaithersburg, MD, USA