Stem Cell Related Patent Number US7097823

High dose radionuclide complexes for bone marrow suppression

Fritzberg, Alan R.; Olga, WA, United States of America
Abrams, Paul G.; Seattle, WA, United States of America
Tatalick, Lauren Marie; Redmond, WA, United States of America
Thoelke, Kent R.; Seattle, WA, United States of America
Bryan, James Kyle; Seattle, WA, United States of America
Hylarides, Mark D.; Stanwood, WA, United States of America
John, Elizabeth K.; San Diego, CA, United States of America

This invention describes a method for the treatment of osteomyelitis, in which a composition comprising a ligand-complexed radionuclide is administered to a subject suffering from osteomyelitis. Methods are also disclosed for the suppression of bone marrow in the treatment of cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid. Methods are also described for the augmentation of the subject