Stem Cell Related Patent Number US6284539
Method for generating dopaminergic cells derived from neural precursors
Bowen, David C.; Washington, DC, USA
This invention introduces a novel process for the production of cells that express tyrosine hydroxylase, via the transformation of central nervous system stem cells with a transcriptional regulator.. Described herein are methods by which the differentiation of multipotential precursor cells from the central nervous system may be directed, such that the gene coding for the nuclear receptor, Nurr1, is introduced into the central nervous system (CNS) stem cells, thereby causing the cells to adopt a dopaminergic cell fate. Therapeutic applications include the treatment of injured or degenerate dopaminergic cells, such as in Parkinson’s Disease or other neurological disorders.
Application Number: US1998000169309
Date Filed: 10/09/98
Dated Published: 09/04/01
Assignee: NeuralStem Biopharmaceuticals, Ltd., College Park, MD, USA