Stem Cell Related Patent Number US6211146

60A protein-induced morphogenesis

Kuberasampath, Thangavel; Medway, MA, USA
Pang, Roy H. L.; Etna, NH, USA
Oppermann, Hermann; Medway, MA, USA
Rueger, David C.; Hopkinton, MA, USA
Cohen, Charles M.; Medway, MA, USA

Described herein are drosophila 60A protein morphogenically active fragments, and methods of their use in the induction of tissue morphogenesis. The invention relates to methods of utilizing a morphogenically active fragment of 60A protein to induce tissue morphogenesis and to increase a mammalian progenitor cell population. Further disclosed are methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, as well as methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.

Application Number: US1994000271556

Date Filed: 07/07/94

Dated Published: 04/03/01

Assignee: Curis, Inc.