Stem Cell Related Patent Number US6093531

Generation of hematopoietic cells from multipotent neural stem cells

Bjornson, Christopher R.; Seattle, WA, USA
Rietze, Rod L.; Brunswick, Australia
Reynolds, Brent A.; Saltspring, Canada
Vescovi, Angelo L.; Milan, Italy

Described herein are methods of generating hematopoietic cells from multipotent neural stem cells (MNSC) and their progeny. The invention relates to a process by which the MNSC progeny are placed in a hematopoietic-inducing environment which can be either ex vivo or in vivo, such as a mammal’s circulatory system which can induce xenogeneic, allogeneic, or autologous MNSC progeny to generate a full complement of hematopoietic cells. Therapeutic applications include the use of MNSC progeny as an alternative to bone marrow and hematopoietic stem cell transplantation in the treatment of blood-related disorders.

Application Number: US1998000100679

Date Filed: 06/19/98

Dated Published: 07/25/00

Assignee: NeuroSpheres Holdings Ltd., Calgary, Canada