Stem Cell Related Patent Number US6027917

Bone morphogenetic protein (BMP)-17 and BMP-18 compositions

Celeste, Anthony J.; Hudson, MA, USA

This invention introduces the novel purified bone morphogenic protein-17 and -18 (BMP-17 and BMP-18) polypeptides, methods and uses thereof. Further disclosed are properties of the DNA molecules encoding the BMP-17 and BMP-18 proteins, as well as methods by which the proteins maybe utilized for inducing the growth and differentiation of undifferentiated embryonic stem cells. Therapeutic applications include the use of such proteins in the treatment of disorders of the bone, cartilage, and other connective tissue, including cardiac, hepatic, neurological and renal tissue.

Application Number: US1997000987904

Date Filed: 12/10/97

Dated Published: 02/22/00

Assignee: Genetics Institute, Inc., Cambridge, MA, USA