Stem Cell Related Patent Number US5766581

Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation

Bartley, Timothy D.; Thousand Oaks, CA, USA
Bogenberger, Jakob M.; Camarillo, CA, USA
Bosselman, Robert A.; Thousand Oaks, CA, USA
Hunt, Pamela; Thousand Oaks, CA, USA
Kinstler, Olaf B.; Thousand Oaks, CA, USA
Samal, Babru B.; Moorpark, CA, USA

This invention discloses mammalian treatment methods involving proteins referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately resulting in the production of platelets. Also disclosed are MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol. Methods of preparation and treatment are emphasized. This invention is an expansion of number US5795569, in which the novel properties of MGDFs were introduced.

Application Number: US1995000413803

Date Filed: 03/30/95

Dated Published: 06/16/98

Assignee: Amgen Inc., Thousand Oaks, CA, USA