Stem Cell Related Patent Number US7115417

Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor compositions, and treatments thereof

Chancellor, Michael B.; Pittsburg, PA, United States of America
Huard, Johnny; Pittsburgh, PA, United States of America
Capelli, Christopher C.; Kenosha, WI, United States of America
Qu, Zhuqing; Pittsburgh, PA, United States of America

Described herein is the use of a composition comprising isolated muscle-derived progenitor cells (MDCs) expressing cell markers having long-term survivability in situ. This invention relates to muscle-derived progenitor cells that exhibit an ability to survive long-term following transplantation into body tissue, resulting in the augmentation of soft tissue. Also included are such methods of introduction, which include injection, transplantation, and implantation. Methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy are further described, as are methods of suspension, isolation and plating. The invention additionally provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, such as malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.

Application Number: US2000000549937

Date Filed: 04/14/00

Dated Published: 10/03/06

Assignee: None