Stem Cell Related Patent Number US7132287

Method for neural stem cell differentiation using 5HT-1A agonists

Rajan, Prithi; Rockville, MD, United States of America

This invention describes a method of preparing populations of enriched mammalian neural cells via exposure of the neural stem cell population to a 5-hydroxytryptamine receptor (5HT1A) agonist. Disclosed herein are the means for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron, in vitro or in vivo, with an agonist such as buspirone. Amounts and frequencies of exposure to the agonist are included, such that conditions are sufficient for inducing differentiation, and for the expression of a neuronal cell marker. Therapeutic applications in the treatment of autism and stroke are also provided.

Application Number: US2002000175360

Date Filed: 06/18/02

Dated Published: 11/07/06

Assignee: Psychiatric Genomics, Inc., Gaithersburg, MD, United States of America