Stem Cell Related Patent Number US6174333

Biomatrix for soft tissue regeneration using mesenchymal stem cells

Kadiyala, Sudhakar; Baltimore, MD, USA
Caplan, Arnold I.; Cleveland Heights, OH, USA
Fink, David J.; Shaker Heights, OH, USA
Young, Randall G.; Ellicott City, MD, USA

Described herein is an implant for the repair of mammalian tissue defects. The invention relates to a contracted gel matrix formed in a planar mat with a plurality of physiologically compatible load-bearing sutures for securing tissue under tension adjacent to the defect to be repaired. Further disclosed are properties of the sutures for supporting a tissue reparative cell mass in the defect such that the sutures have a central portion encapsulated in a cell-containing matrix which is contracted under a tensile load by the cells and formed into a mat sheet during the contraction to which spring metal wires hold the sutures under tension during the contraction. The matrix is described as being a collagen gel or other material which the cells contract, with the cells constituting human mesenchymal stem cells. Also provided are methods by which the mat sheet is rolled into a spiral roll with the sutures extending from opposite roll ends to form the desired implant. Multiple embodiments of the invention are provided.

Application Number: US1998000222688

Date Filed: 12/29/98

Dated Published: 01/16/01

Assignee: Osiris Therapeutics, Inc., Baltimore, MD, USA